{"id":"W4220914817","doi":"10.1186/s12879-022-07256-y","title":"Durable reduction of Clostridioides difficile infection recurrence and microbiome restoration after treatment with RBX2660: results from an open-label phase 2 clinical trial","year":2022,"lang":"en","type":"article","venue":"BMC Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Regional Laboratory Medicine Program; University of British Columbia; Island Health","funders":"","keywords":"Medicine; Clostridioides; Adverse effect; Internal medicine; Diarrhea; Antibiotics; Open label; Clinical trial; Prospective cohort study; Retrospective cohort study; Medical microbiology; Surgery; Pediatrics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004408554,0.0003046113,0.0006194465,0.0002836037,0.0004183544,0.0001261454,0.0001153701,0.0001081365,0.0001810271],"category_scores_gemma":[0.0003370822,0.000261079,0.0000974158,0.0006139189,0.0002473427,0.0003446418,0.0001859525,0.0002980588,0.000007457196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005385884,"about_ca_system_score_gemma":0.0008992848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003340683,"about_ca_topic_score_gemma":0.0003849604,"domain_scores_codex":[0.9968957,0.0006064266,0.0008568379,0.0008497539,0.0004660704,0.0003252035],"domain_scores_gemma":[0.9980886,0.0002779745,0.0003939439,0.0006648346,0.000244761,0.0003298602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7732127,0.05677542,0.07354074,0.0001785093,0.0005245563,0.0001230623,0.000590414,0.0001511695,0.05270404,0.00002715546,0.001743319,0.04042891],"study_design_scores_gemma":[0.673089,0.2102233,0.05892629,0.0003760582,0.002466332,0.0003907687,0.0008321577,0.001424315,0.04491774,0.0001533353,0.00598059,0.001220127],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942837,0.0005612081,0.0000288152,0.0001047209,0.0005012864,0.002448326,0.001809712,0.0001095981,0.0001526],"genre_scores_gemma":[0.9960131,0.0006553135,0.00009791484,0.00002478877,0.000573745,0.0007118956,0.001681346,0.00004176367,0.0002001398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1534479,"threshold_uncertainty_score":0.9999841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08422327532946881,"score_gpt":0.3960857084859053,"score_spread":0.3118624331564365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}