{"id":"W4220915428","doi":"10.1101/2022.03.13.484176","title":"<i>In vivo</i> CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Institute for Research in Immunology and Cancer; Toronto General Hospital; University Health Network; University of Toronto; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Krembil Foundation; University of Toronto","keywords":"KRAS; Cancer research; Cytotoxic T cell; Immunotherapy; Immune system; Biology; Tumor microenvironment; Lung cancer; Cancer; Cancer immunotherapy; Immunology; Medicine; Colorectal cancer; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002840036,0.0004445111,0.0004185542,0.0003172093,0.0002117531,0.0005506648,0.0002872189,0.0003976086,0.002543067],"category_scores_gemma":[0.0001538589,0.0001881862,0.0004077884,0.0001573327,0.0002698036,0.000135583,0.0002876294,0.0006384097,0.0007115955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004393137,"about_ca_system_score_gemma":0.0002438751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008892188,"about_ca_topic_score_gemma":0.001468009,"domain_scores_codex":[0.999689,0.00004460663,0.00003512472,0.00006698203,0.0001093408,0.00005485689],"domain_scores_gemma":[0.9998079,0.00004212639,0.00006490318,0.00002409203,0.00002045015,0.00004043049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006173738,0.00001816998,0.0003118908,0.00002335102,0.000008214977,0.00007996767,0.00000846712,0.0002176454,0.9977075,0.00012031,0.0001425953,0.001300173],"study_design_scores_gemma":[0.00001217135,0.0001708948,0.002769786,0.000004353062,0.00002458287,0.0003683749,0.00002081849,0.002429574,0.9903046,0.00006593629,0.003821929,0.000006950211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594522,0.001333405,0.0254493,0.0005389835,0.00009009951,0.0001804211,0.004326549,0.001604372,0.007024697],"genre_scores_gemma":[0.9843968,0.0004139179,0.008854025,0.0001767222,0.00001269072,0.00007854501,0.001435652,0.0001473052,0.00448433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002543067,"threshold_uncertainty_score":0.008507371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009251355233958793,"score_gpt":0.248397350471176,"score_spread":0.2391459952372172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}