{"id":"W4220917175","doi":"10.21203/rs.3.rs-1416934/v1","title":"Language Impairment in the Genetic Forms of Behavioural Variant Frontotemporal Dementia","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University; University of Toronto; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; Medical Research Council; Tau Consortium; UK Dementia Research Institute; Stichting Dioraphte; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Università degli Studi di Brescia; University of Toronto; Universidade de Coimbra; Alzheimer's Society; Ministero della Salute; Stockholms Läns Landsting; Toronto Rehabilitation Institute; Weston Brain Institute; ZonMw; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Wolfson Foundation; Wellcome Trust; University College London; University of Cambridge; National Brain Appeal; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; University Health Network; Brain Research UK; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer Nederland; Sunnybrook Research Institute; Università degli Studi di Milano; Canadian Institutes of Health Research; London School of Hygiene and Tropical Medicine","keywords":"Frontotemporal dementia; Psychology; C9orf72; Primary progressive aphasia; Verbal fluency test; Boston Naming Test; Audiology; Aphasia; Fluency; Dementia; Cognitive psychology; Neuropsychology; Medicine; Cognition; Pathology; Disease; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003926357,0.0007094044,0.0004155746,0.001396656,0.0006358663,0.0006000172,0.0003379024,0.0006750292,0.002058298],"category_scores_gemma":[0.001392155,0.0002135261,0.0002424244,0.000496169,0.0005907721,0.000394649,0.0005795192,0.0002892968,0.0003557888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004651162,"about_ca_system_score_gemma":0.000216842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007409737,"about_ca_topic_score_gemma":0.008684492,"domain_scores_codex":[0.9997163,0.0000602022,0.00003078072,0.00007641732,0.00005615429,0.00006009677],"domain_scores_gemma":[0.9996438,0.00007745353,0.0001518106,0.00001777458,0.00004886484,0.00006031069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002311389,0.0002850767,0.9453734,0.0001307151,0.0001634969,0.01976006,0.001514407,0.0001906567,0.0147688,0.0001521749,0.0004553308,0.01489455],"study_design_scores_gemma":[0.00002876423,0.0004253935,0.9805154,0.00003461462,0.00005158779,0.0171854,0.0005255615,0.0001557106,0.0005101639,0.0002894001,0.0002678365,0.00001033363],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989662,0.0002158448,0.00003403192,0.00002721054,0.000003332104,0.000005734918,0.00007971921,0.000004043741,0.0006638708],"genre_scores_gemma":[0.999713,0.00004460596,0.00003658449,0.00001725624,0.000004450579,0.000002542964,0.0000576497,9.596308e-7,0.0001229648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007409737,"threshold_uncertainty_score":0.01473325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06595260972644992,"score_gpt":0.4072538483977278,"score_spread":0.3413012386712779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}