{"id":"W4220918829","doi":"10.1016/j.jaac.2021.11.035","title":"Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms","year":2022,"lang":"en","type":"review","venue":"Journal of the American Academy of Child & Adolescent Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Agencia Estatal de Investigación; Helse Sør-Øst RHF; Medical Research Council; National Institutes of Health; National Institute on Aging; Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Novo Nordisk Fonden; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Norges Forskningsråd; Virginia Commonwealth University; Vetenskapsrådet; National Institute on Drug Abuse; Novo Nordisk; Generalitat de Catalunya; Jacobs Foundation; H2020 Fast Track to Innovation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Alliance for Research on Schizophrenia and Depression; ZonMw; Koninklijke Nederlandse Akademie van Wetenschappen; European Commission; Wellcome Trust; University College London; University of Bristol; National Institute of Mental Health; Children's Hospital Foundation; Centres de Recerca de Catalunya; Gujarat Council on Science and Technology; Diabetesforbundet; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministerio de Ciencia, Innovación y Universidades; University of Queensland; Queensland Health; National Health and Medical Research Council; American Academy of Child and Adolescent Psychiatry; National Institute on Alcohol Abuse and Alcoholism; Bergens Forskningsstiftelse; Universitetet i Bergen; Academy of Finland; University of South Dakota; Stiftelsen Kristian Gerhard Jebsen","keywords":"Heritability; Loneliness; Anxiety; Genetic architecture; Psychology; Autism spectrum disorder; Psychiatry; Comorbidity; Clinical psychology; Autism; Medicine; Population; Genetics; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006290641,0.00228167,0.00719732,0.003245993,0.0002857121,0.001591848,0.001555984,0.001414653,0.002748926],"category_scores_gemma":[0.009656572,0.0007587333,0.01160285,0.00403009,0.0002983226,0.0007132632,0.001069819,0.001727755,0.0003413505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001046229,"about_ca_system_score_gemma":0.002189773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003854902,"about_ca_topic_score_gemma":0.007789778,"domain_scores_codex":[0.9976277,0.001271109,0.000326473,0.0003925336,0.0002802196,0.0001021061],"domain_scores_gemma":[0.9947467,0.00405725,0.000490265,0.0002036701,0.0004040816,0.00009798905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002603209,0.0000687969,0.01417102,0.1684262,0.5244066,0.0003755376,0.00009014646,0.001742615,0.0007350165,0.001285883,0.009386488,0.2767085],"study_design_scores_gemma":[0.0009299804,0.0005187108,0.03930471,0.03710881,0.8767253,0.0009575859,0.00009723972,0.001098521,0.0007985753,0.003704604,0.03865559,0.0001005198],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0008527724,0.9981685,0.0003254451,0.0002517319,0.0001079042,0.00001554148,0.0001337739,0.00001385269,0.0001304169],"genre_scores_gemma":[0.02323304,0.9744177,0.001066899,0.0003783668,0.0002458382,0.0000790436,0.000416093,0.00001407597,0.0001491135],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00719732,"threshold_uncertainty_score":0.03326851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02801399931239818,"score_gpt":0.3171308153068942,"score_spread":0.2891168159944961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}