{"id":"W4220919975","doi":"10.1038/s41431-022-01054-5","title":"Receiving results of uncertain clinical relevance from population genetic screening: systematic review & meta-synthesis of qualitative research","year":2022,"lang":"en","type":"review","venue":"European Journal of Human Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Relevance (law); Cognitive reframing; Qualitative research; Population; Clinical significance; Psychology; Medicine; Clinical psychology; Social psychology; Pathology; Sociology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1096955,0.002275497,0.009634935,0.01686373,0.001669236,0.006758161,0.003150295,0.002449469,0.006645124],"category_scores_gemma":[0.3109511,0.002162788,0.01163303,0.01623067,0.002716614,0.006191781,0.005844282,0.00260427,0.0005053636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01424394,"about_ca_system_score_gemma":0.02912784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008691847,"about_ca_topic_score_gemma":0.02075334,"domain_scores_codex":[0.8991574,0.06426894,0.0233185,0.003414603,0.008111198,0.001729345],"domain_scores_gemma":[0.713955,0.2439786,0.02204519,0.006870508,0.01213749,0.001013138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003404094,0.00001734495,0.0008963174,0.9544568,0.01291012,0.0001212038,0.00474224,0.0002594128,0.000186221,0.001133358,0.001522784,0.0234138],"study_design_scores_gemma":[0.0003255287,0.0001958703,0.001901451,0.9146856,0.05643734,0.0002032413,0.006158963,0.000194887,0.0006156984,0.002700517,0.01649628,0.0000846668],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01402627,0.9472533,0.01039108,0.004804627,0.001018361,0.01523175,0.005150509,0.0001211447,0.002003067],"genre_scores_gemma":[0.1880057,0.7093547,0.03528379,0.004613029,0.0003153158,0.05872645,0.00245388,0.0001265385,0.001120587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1096955,"threshold_uncertainty_score":0.5801321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5047150321181062,"score_gpt":0.5369618611748863,"score_spread":0.03224682905678011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}