{"id":"W4220922945","doi":"10.1128/jcm.02283-21","title":"Highly Sensitive Lineage Discrimination of SARS-CoV-2 Variants through Allele-Specific Probe PCR","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Microbiology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 Health; NIHR Imperial Biomedical Research Centre; Medical Research Council; National Health and Medical Research Council; Fundação Lemann; European Commission; Minderoo Foundation; University of Oxford; Canadian Institutes of Health Research; National Institute for Health and Care Research; Health Research Board; AstraZeneca; Translational Breast Cancer Research Consortium; Wellcome Trust; Pittsburgh Foundation","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Lineage (genetic); Virology; Coronavirus disease 2019 (COVID-19); DNA sequencing; 2019-20 coronavirus outbreak; Allele; Genetics; Polymerase chain reaction; Gold standard (test); Computational biology; Gene; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009359475,0.0007688543,0.0003324166,0.0008135285,0.0002301422,0.000557782,0.0003275159,0.0009280524,0.005611651],"category_scores_gemma":[0.001656133,0.0004634,0.0002417534,0.0004529421,0.0003825956,0.00042894,0.0003549838,0.0009191468,0.002306052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002266514,"about_ca_system_score_gemma":0.0002614355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002481338,"about_ca_topic_score_gemma":0.00102005,"domain_scores_codex":[0.9984306,0.0004094552,0.0001296778,0.0005415576,0.0003180901,0.0001704908],"domain_scores_gemma":[0.9993179,0.0002809651,0.000126935,0.00005228293,0.0001477051,0.00007413221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057633,0.00003679035,0.002402857,0.00004945615,0.000006845551,0.00004388631,0.00007130527,0.00007232615,0.9909601,0.0001271527,0.0001317502,0.005991859],"study_design_scores_gemma":[0.00002862231,0.0005231738,0.02323217,0.0000399146,0.00003964045,0.0009730851,0.0001328725,0.003320282,0.9638416,0.0003738491,0.007466494,0.00002834616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8504977,0.001689177,0.1341197,0.0003430502,0.000151569,0.0004566961,0.003027217,0.001076984,0.008638036],"genre_scores_gemma":[0.776158,0.0008136536,0.2069121,0.0004146164,0.00004028267,0.0005106946,0.004051325,0.0001792703,0.01092012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005611651,"threshold_uncertainty_score":0.01877284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1492386314598171,"score_gpt":0.4310950799217393,"score_spread":0.2818564484619223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}