{"id":"W4220925839","doi":"10.18632/aging.203936","title":"Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis","year":2022,"lang":"en","type":"article","venue":"Aging","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Medical Research Council; Dartmouth College; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Cystic Fibrosis Foundation; Burroughs Wellcome Fund","keywords":"Epigenetics; DNA methylation; Senescence; New guinea; Cellular senescence; Methylation; DNA; Biology; Andrology; Genetics; Gerontology; Medicine; History; Ethnology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008599099,0.0001399178,0.0002988874,0.0002250578,0.0002139543,0.00001834379,0.00006687408,0.00004164817,0.00008261045],"category_scores_gemma":[0.0001397544,0.0001195174,0.0000243587,0.0003171222,0.00008741045,0.00007233318,0.0001472511,0.0003944976,0.000001360024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000717484,"about_ca_system_score_gemma":0.00005115188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102437,"about_ca_topic_score_gemma":0.000176985,"domain_scores_codex":[0.9984845,0.0003157054,0.0002222445,0.0003814487,0.000236811,0.0003592733],"domain_scores_gemma":[0.9992862,0.0002357927,0.00005029649,0.000225854,0.00003981312,0.0001620024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000781909,0.00004858603,0.8823789,0.000186269,0.00005769754,0.0001734082,0.001479063,0.0001176646,0.1132075,0.00006427118,0.0001750891,0.002033367],"study_design_scores_gemma":[0.001855433,0.0003011183,0.9826726,0.0001923894,0.00009800687,0.0002088201,0.001074107,0.005426269,0.00568151,0.0002367971,0.001994594,0.0002583713],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905919,0.004473361,0.0002540907,0.004064316,0.00001888984,0.0003143893,0.000004869526,0.00003364109,0.00024452],"genre_scores_gemma":[0.9977021,0.0003033482,0.0008004757,0.0009600225,0.00005204034,0.00005516289,0.00003775254,0.00002112482,0.00006792806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.107526,"threshold_uncertainty_score":0.4873776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150912003204022,"score_gpt":0.2783012647530274,"score_spread":0.2632100644326252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}