{"id":"W4220925839","doi":"10.18632/aging.203936","title":"Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis","year":2022,"lang":"en","type":"article","venue":"Aging","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Medical Research Council; Dartmouth College; National Cancer Institute; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Cystic Fibrosis Foundation; Burroughs Wellcome Fund","keywords":"Epigenetics; DNA methylation; Senescence; New guinea; Cellular senescence; Methylation; DNA; Biology; Andrology; Genetics; Gerontology; Medicine; History; Ethnology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003171403,0.0001898139,0.0001513258,0.0003520945,0.0001986714,0.0002591012,0.0001091649,0.0003635792,0.002091144],"category_scores_gemma":[0.0003543696,0.0001452465,0.0001888436,0.000149162,0.0003240118,0.0001452936,0.0002727822,0.000284052,0.0001485635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000140557,"about_ca_system_score_gemma":0.0001280215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401889,"about_ca_topic_score_gemma":0.001530887,"domain_scores_codex":[0.9999132,0.000030347,0.000003100664,0.00002712929,0.000007250118,0.00001896819],"domain_scores_gemma":[0.9998425,0.00002596758,0.00006721483,0.00001907105,0.00001207628,0.00003311717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003013074,0.0003957182,0.8010728,0.0002440445,0.0002701793,0.00100603,0.001068269,0.000163283,0.1694911,0.0004762987,0.0006168153,0.02218238],"study_design_scores_gemma":[0.00001766014,0.0008867338,0.992603,0.00004311479,0.00006525523,0.0009496459,0.0004425244,0.0001979444,0.003479427,0.0002242211,0.001081847,0.00000856489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980667,0.0007699023,0.000356135,0.0001259996,0.00001863858,0.000006585537,0.0001951371,0.00000811767,0.0004527091],"genre_scores_gemma":[0.9988483,0.0003170043,0.0002497731,0.00008424831,0.000006720043,0.00001300027,0.0001126947,0.000002266139,0.0003660113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002091144,"threshold_uncertainty_score":0.006995559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150912003204022,"score_gpt":0.2783012647530274,"score_spread":0.2632100644326252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}