{"id":"W4220926696","doi":"10.1177/13524585221076717","title":"Effect of siponimod on magnetic resonance imaging measures of neurodegeneration and myelination in secondary progressive multiple sclerosis: Gray matter atrophy and magnetization transfer ratio analyses from the EXPAND phase 3 trial","year":2022,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Novartis Pharmaceuticals Corporation","keywords":"Atrophy; White matter; Multiple sclerosis; Magnetic resonance imaging; Magnetization transfer; Medicine; Neurodegeneration; Pathology; Radiology; Disease; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001562645,0.0007742997,0.001478954,0.0002734971,0.0001890886,0.0004547568,0.0002806497,0.0006049951,0.003252746],"category_scores_gemma":[0.001161533,0.0001919429,0.001214123,0.0001967923,0.0003260656,0.0005061559,0.000250984,0.001181056,0.0003480389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002647949,"about_ca_system_score_gemma":0.0004291201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002886219,"about_ca_topic_score_gemma":0.001028849,"domain_scores_codex":[0.9996816,0.0001663117,0.00002911562,0.00003725966,0.00004379689,0.00004187314],"domain_scores_gemma":[0.9993184,0.0002129944,0.0002088632,0.00005407352,0.0000597351,0.000146013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8579679,0.005846113,0.007745794,0.001893023,0.003838184,0.0001789989,0.0001740444,0.00145635,0.02742813,0.0002022853,0.001940061,0.09132919],"study_design_scores_gemma":[0.369699,0.4875471,0.1165235,0.0003229394,0.006301342,0.000560641,0.0001124086,0.002517261,0.01161576,0.000498416,0.00423165,0.00007002962],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935255,0.003240114,0.0002337241,0.0001220084,0.00003928646,0.0005068871,0.0009616092,0.000048573,0.001322196],"genre_scores_gemma":[0.9951139,0.001300503,0.0006011107,0.0001975128,0.00008133903,0.0006737888,0.001027148,0.0000124889,0.0009921832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003252746,"threshold_uncertainty_score":0.01088154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0797690790076609,"score_gpt":0.3194440112167253,"score_spread":0.2396749322090644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}