{"id":"W4220932190","doi":"10.1016/j.cbi.2022.109882","title":"Lysosomal cysteine proteases are mediators of cell death in macrophages following exposure to amorphous silica nanoparticles","year":2022,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tertiary Education Trust Fund; Queen's University; Queen's University Belfast","keywords":"Proteases; Programmed cell death; Cysteine protease; Extracellular; Nanotoxicology; Pyroptosis; Protease; Cell biology; Chemistry; Apoptosis; Cysteine; Biochemistry; Toxicity; Biology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018216,0.0002579383,0.0002101488,0.0002294787,0.000145547,0.0002132087,0.00009069518,0.0003606768,0.0007363727],"category_scores_gemma":[0.0001594854,0.0001081986,0.0002108807,0.000129272,0.0003146809,0.0001876124,0.0001765908,0.0002638517,0.0001897726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102777,"about_ca_system_score_gemma":0.0001264145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002023236,"about_ca_topic_score_gemma":0.0003390221,"domain_scores_codex":[0.9997939,0.00005004767,0.00002091732,0.00002949415,0.0000628239,0.00004278449],"domain_scores_gemma":[0.9998771,0.00002631832,0.00004268119,0.00001338135,0.00002497345,0.00001553824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001654801,0.0000109221,0.0006290048,0.00003526489,0.000004565999,0.0001614667,0.00004162891,0.00001684262,0.9982545,0.00002706226,0.000009700352,0.0006435728],"study_design_scores_gemma":[0.00001298587,0.0005229414,0.0167338,0.0000121874,0.00001809928,0.0009084785,0.0001635983,0.0002570916,0.9804012,0.0001265994,0.0008378284,0.000005186232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944901,0.002317896,0.00209565,0.00006963865,0.00001414145,0.00002681994,0.00008115521,0.00002010817,0.0008844135],"genre_scores_gemma":[0.9965508,0.000782915,0.00120177,0.00003906689,0.00001157897,0.00003648115,0.00007828858,0.000003716052,0.001295431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007363727,"threshold_uncertainty_score":0.00246346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242070791144353,"score_gpt":0.2506668242229346,"score_spread":0.238246116311491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}