{"id":"W4220932190","doi":"10.1016/j.cbi.2022.109882","title":"Lysosomal cysteine proteases are mediators of cell death in macrophages following exposure to amorphous silica nanoparticles","year":2022,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tertiary Education Trust Fund; Queen's University; Queen's University Belfast","keywords":"Proteases; Programmed cell death; Cysteine protease; Extracellular; Nanotoxicology; Pyroptosis; Protease; Cell biology; Chemistry; Apoptosis; Cysteine; Biochemistry; Toxicity; Biology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004263,0.000162696,0.000224334,0.00006998983,0.000119832,0.00001008914,0.0002524334,0.00007597371,0.0001523539],"category_scores_gemma":[0.0001848215,0.0001468692,0.0001816323,0.0001887299,0.00004190594,0.000007148792,0.0003084282,0.0001906172,0.000009195766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004113167,"about_ca_system_score_gemma":0.00003275566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003281258,"about_ca_topic_score_gemma":0.00001857344,"domain_scores_codex":[0.9988602,0.00008372956,0.0003404996,0.0003399099,0.0001030193,0.0002726341],"domain_scores_gemma":[0.9994822,0.00003694964,0.000123358,0.0002514534,0.00003837168,0.0000676605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000179457,0.0003059402,0.03094363,0.00001029446,0.00002828289,0.00001742515,0.0001087915,0.0001806503,0.9677531,0.000005107968,0.0003371002,0.0001302411],"study_design_scores_gemma":[0.0005142182,0.0006526795,0.00680036,0.00001340596,0.00001201041,0.00001338603,0.00145541,0.000006748237,0.9862671,0.0000206294,0.004062976,0.0001810903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983194,0.0005937028,0.00001006844,0.0001455225,0.0001809177,0.0003037597,0.00005546263,0.00001930781,0.0003718799],"genre_scores_gemma":[0.9987921,0.00002748464,0.0001666422,0.0002084888,0.00005260851,0.0003419158,0.0001357543,0.00001544415,0.0002596179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02414327,"threshold_uncertainty_score":0.5989155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242070791144353,"score_gpt":0.2506668242229346,"score_spread":0.238246116311491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}