{"id":"W4220932718","doi":"10.1186/s40164-022-00268-z","title":"Matching-adjusted indirect treatment comparison of chimeric antigen receptor T-cell therapies for third-line or later treatment of relapsed or refractory large B-cell lymphoma: lisocabtagene maraleucel versus tisagenlecleucel","year":2022,"lang":"en","type":"article","venue":"Experimental Hematology and Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; EVERSANA (Canada)","funders":"Bristol-Myers Squibb; American Society of Hematology","keywords":"Medicine; Oncology; Hazard ratio; Internal medicine; Confidence interval; Cytokine release syndrome; Odds ratio; Chimeric antigen receptor; Immunology; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002373073,0.0004053162,0.001660508,0.0002734307,0.0003076189,0.000005485936,0.0001625678,0.0002979404,0.003685311],"category_scores_gemma":[0.00001054347,0.0002927381,0.0002591597,0.0002456123,0.0003128765,0.00004862291,0.0001324875,0.0001480069,0.00001150555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009284829,"about_ca_system_score_gemma":0.0004858774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001515292,"about_ca_topic_score_gemma":0.0001281415,"domain_scores_codex":[0.9973783,0.000466851,0.0007682974,0.0005664786,0.0002548097,0.0005652153],"domain_scores_gemma":[0.998152,0.0007842827,0.0004415858,0.0004042657,0.00005800895,0.0001599252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1469721,0.04869827,0.006349076,0.00028331,0.001422371,0.0002659425,0.03714463,0.000005012665,0.7420595,0.0001010662,0.00172985,0.01496889],"study_design_scores_gemma":[0.05965948,0.07529414,0.0004607794,0.00001565509,0.00019029,0.0001819709,0.01633826,0.0001123167,0.7907352,0.000008381434,0.05676214,0.0002414105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751572,0.02080475,0.00001448125,0.0001983401,0.0006070173,0.001847465,0.0001620491,0.00005576327,0.001152913],"genre_scores_gemma":[0.984604,0.001817412,0.001844116,0.00009423048,0.00007788021,0.000770928,0.0003024689,0.00007013754,0.01041882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08731266,"threshold_uncertainty_score":0.9999525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07916506812500414,"score_gpt":0.3910096793426737,"score_spread":0.3118446112176696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}