{"id":"W4220933445","doi":"10.21203/rs.3.rs-1475049/v1","title":"Mucin foraging enables Akkermansia muciniphila to compete against other microbes in the gut and to modulate host sterol biosynthesis","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; American Heart Association","keywords":"Akkermansia muciniphila; Mucin; Host (biology); Sterol; Biology; Foraging; Microbiology; Biosynthesis; Ecology; Biochemistry; Gut flora; Cholesterol; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259223,0.000335419,0.0001853328,0.0001519558,0.0001841391,0.0003551115,0.0001857066,0.0004470439,0.001192808],"category_scores_gemma":[0.000162715,0.0001188786,0.0002907382,0.0001162168,0.0002295977,0.000272554,0.0006669727,0.0004749548,0.0004729317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001990153,"about_ca_system_score_gemma":0.0001839762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193047,"about_ca_topic_score_gemma":0.0007121761,"domain_scores_codex":[0.9999044,0.00001227379,0.000006857618,0.00002260477,0.00001991296,0.00003385874],"domain_scores_gemma":[0.9998987,0.00002042833,0.00002875081,0.00001632498,0.000009582931,0.00002634476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003282312,0.00001031228,0.0003513861,0.00001159817,0.000002007363,0.00003469707,0.00001046884,0.00002835692,0.9989409,0.00006698178,0.00001588057,0.0004945056],"study_design_scores_gemma":[0.0000279429,0.0003869871,0.0324599,0.00001452168,0.00002093022,0.0007551814,0.0002846337,0.003370427,0.9573407,0.0004152878,0.004905011,0.00001839497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960536,0.0002893608,0.002276568,0.0001643822,0.00002767515,0.000008740016,0.0001222687,0.00005755903,0.0009997236],"genre_scores_gemma":[0.9943428,0.0001516272,0.002857931,0.00006875527,0.00001011835,0.00001204111,0.0002558972,0.00002447417,0.002276423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193047,"threshold_uncertainty_score":0.003990352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04078046886030175,"score_gpt":0.3379747336025053,"score_spread":0.2971942647422036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}