{"id":"W4220936304","doi":"10.1101/2022.03.10.483772","title":"Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Saskatchewan; University of Calgary; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Research Nova Scotia; Canadian Institutes of Health Research; Dalhousie University; Innovation Saskatchewan","keywords":"GTPase; Biology; Spike (software development); Glycoprotein; Coronavirus; RAC1; Viral entry; Receptor; Virus; Cell biology; Virology; Viral replication; Molecular biology; Biochemistry; Signal transduction; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008433979,0.0002356752,0.0001489751,0.0001439576,0.00008935215,0.0001746071,0.0001704749,0.0002021298,0.001257345],"category_scores_gemma":[0.0001348241,0.00008512696,0.0001518915,0.00006315273,0.0001158079,0.0001074255,0.0001081101,0.0003636383,0.0003123822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009438518,"about_ca_system_score_gemma":0.00009938674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004321439,"about_ca_topic_score_gemma":0.0005425044,"domain_scores_codex":[0.9999233,0.00001770999,0.000008610604,0.00001152239,0.00002259782,0.0000161853],"domain_scores_gemma":[0.9998678,0.00004331221,0.00002935451,0.00002052009,0.00001868226,0.00002037015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106212,0.00003772368,0.00009758723,0.00002439697,0.000006357397,0.00001706129,0.000008123073,0.00006214,0.9977294,0.00002917219,0.00002649762,0.001851032],"study_design_scores_gemma":[0.00001159973,0.0007399418,0.00125133,0.000002573383,0.000006622455,0.00007629311,0.000006897345,0.0005564275,0.9965134,0.00001647825,0.0008167863,0.000001649464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955896,0.001668408,0.001137608,0.00005120238,0.00002329358,0.00002304523,0.0001454381,0.00008351202,0.001277826],"genre_scores_gemma":[0.9960464,0.0007916424,0.001066806,0.00002754464,0.00001566057,0.00001643728,0.0002381501,0.00001431264,0.001783066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257345,"threshold_uncertainty_score":0.0042063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03503041770677205,"score_gpt":0.3041840025791065,"score_spread":0.2691535848723345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}