{"id":"W4220938340","doi":"10.1158/1078-0432.ccr-21-4283","title":"Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, <i>IDH</i> -wildtype: <i>Post Hoc</i> Analysis of the EORTC Randomized Phase III CATNON Trial","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Medac; Brain Tumour Charity; Cancer Australia; National Health and Medical Research Council; Cancer Research UK; Y-mAbs Therapeutics; Agios Pharmaceuticals; Seagen; Douglas Pharmaceuticals; Pfizer; NRG Oncology; Teva Pharmaceutical Industries; Medical Research Council; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Temozolomide; Medicine; Oncology; Radiation therapy; Internal medicine; IDH1; O-6-methylguanine-DNA methyltransferase; Anaplastic astrocytoma; Glioma; Chemoradiotherapy; Isocitrate dehydrogenase; Dacarbazine; Cancer research; Chemotherapy; Methyltransferase; Astrocytoma; Methylation; Biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003879284,0.0002122949,0.001690984,0.0005175876,0.0002377695,0.00002563294,0.000274178,0.0001006253,0.0005618974],"category_scores_gemma":[0.0003601187,0.0001264184,0.0004979295,0.002240076,0.000821782,0.00004863956,0.000131005,0.0007676979,6.679136e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600591,"about_ca_system_score_gemma":0.0005450791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001728953,"about_ca_topic_score_gemma":0.00121137,"domain_scores_codex":[0.9948233,0.001851423,0.0009535112,0.0005958687,0.001329422,0.0004464676],"domain_scores_gemma":[0.9954555,0.003071256,0.0002867271,0.0006901354,0.0002771245,0.0002192681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8871625,0.004254423,0.09306455,0.00001309253,0.003474775,0.0000300164,0.0002448974,0.0001045666,0.00008623408,0.00001952769,0.001029653,0.01051573],"study_design_scores_gemma":[0.9582396,0.01552314,0.02073392,0.00004009114,0.001112087,9.68413e-7,0.00008529767,0.0003648096,0.0001876444,0.000004778529,0.003573968,0.0001336514],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879951,0.005191107,0.000003321682,0.002492337,0.0003425803,0.003800371,0.0001052824,0.00001273119,0.00005718351],"genre_scores_gemma":[0.9950624,0.002918727,0.00006439232,0.0005065083,0.0001436933,0.001125429,0.00004646985,0.00003668008,0.00009576492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07233063,"threshold_uncertainty_score":0.6152382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05724010652066623,"score_gpt":0.4465540215475629,"score_spread":0.3893139150268966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}