{"id":"W4220938340","doi":"10.1158/1078-0432.ccr-21-4283","title":"Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, <i>IDH</i> -wildtype: <i>Post Hoc</i> Analysis of the EORTC Randomized Phase III CATNON Trial","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Medac; Brain Tumour Charity; Cancer Australia; National Health and Medical Research Council; Cancer Research UK; Y-mAbs Therapeutics; Agios Pharmaceuticals; Seagen; Douglas Pharmaceuticals; Pfizer; NRG Oncology; Teva Pharmaceutical Industries; Medical Research Council; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Temozolomide; Medicine; Oncology; Radiation therapy; Internal medicine; IDH1; O-6-methylguanine-DNA methyltransferase; Anaplastic astrocytoma; Glioma; Chemoradiotherapy; Isocitrate dehydrogenase; Dacarbazine; Cancer research; Chemotherapy; Methyltransferase; Astrocytoma; Methylation; Biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002108046,0.0008679864,0.001886831,0.000239622,0.0001864896,0.0006720613,0.0005608428,0.0005737142,0.002465715],"category_scores_gemma":[0.00148681,0.0003208704,0.001750581,0.0002661052,0.0006305547,0.0005745835,0.0002914292,0.001793127,0.0003071381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072496,"about_ca_system_score_gemma":0.001398064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105708,"about_ca_topic_score_gemma":0.003987382,"domain_scores_codex":[0.9992392,0.0005185598,0.00003768164,0.00009551697,0.00003773137,0.00007137658],"domain_scores_gemma":[0.9990694,0.0002897521,0.0002471388,0.00007281405,0.00005395714,0.0002669622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9766046,0.002865078,0.002236466,0.00038105,0.001685848,0.00003131436,0.0000364609,0.000654493,0.00211647,0.00009544301,0.0009669708,0.01232574],"study_design_scores_gemma":[0.733511,0.2437685,0.0151747,0.00006505199,0.002556912,0.00008929819,0.0000564365,0.001659548,0.001216112,0.0003367322,0.001534519,0.00003113532],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994698,0.002260254,0.0001774718,0.0004191514,0.0003167622,0.0006207448,0.000430214,0.00002610464,0.001051289],"genre_scores_gemma":[0.9954219,0.001014379,0.0003994266,0.0004353047,0.0002221492,0.0006128353,0.0006526931,0.000009104563,0.001232147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002465715,"threshold_uncertainty_score":0.01114857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05724010652066623,"score_gpt":0.4465540215475629,"score_spread":0.3893139150268966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}