{"id":"W4220938483","doi":"10.1007/s00210-022-02231-5","title":"Estrogenic impregnation alters pain expression: analysis through functional neuropeptidomics in a surgical rat model of osteoarthritis","year":2022,"lang":"en","type":"article","venue":"Naunyn-Schmiedeberg s Archives of Pharmacology","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec; Canadian Nuclear Laboratories; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Ovariectomized rat; Osteoarthritis; Endocrinology; Calcitonin gene-related peptide; Internal medicine; Calcitonin; Substance P; Somatostatin; Medicine; Placebo; Sham surgery; Neuropeptide; Dynorphin; Estrogen; Opioid peptide; Opioid; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002960333,0.0006695968,0.0005176268,0.0008669469,0.0003008847,0.0003675221,0.0003405816,0.0004871747,0.002488772],"category_scores_gemma":[0.0002042142,0.0003352181,0.0005568731,0.0003858103,0.0007463671,0.0005286411,0.0002410709,0.001196932,0.0003008693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003139683,"about_ca_system_score_gemma":0.000478362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363819,"about_ca_topic_score_gemma":0.003593317,"domain_scores_codex":[0.999744,0.00003548179,0.00001815637,0.00004081254,0.00006476771,0.00009684149],"domain_scores_gemma":[0.9997151,0.00002984004,0.00008462975,0.00002947372,0.00003444191,0.0001064097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004596127,0.000722585,0.0006556843,0.00006695989,0.00001818653,0.0001259752,0.00004770758,0.00005415915,0.9903481,0.0001164691,0.0000606478,0.003187317],"study_design_scores_gemma":[0.0003142454,0.01370891,0.02208466,0.00003154662,0.000158918,0.0002767077,0.000458997,0.0006393188,0.9606273,0.0001860675,0.001476541,0.00003673339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959359,0.001573457,0.001079228,0.0001732838,0.00006620104,0.00003051578,0.0003824634,0.00002872708,0.0007299883],"genre_scores_gemma":[0.9888815,0.002842193,0.001493571,0.0001079982,0.00003326139,0.0001089576,0.0004034803,0.00002876316,0.006100097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002488772,"threshold_uncertainty_score":0.008325756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03262442184010332,"score_gpt":0.3208854432987445,"score_spread":0.2882610214586412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}