{"id":"W4220941317","doi":"10.1016/j.celrep.2022.110467","title":"Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council","keywords":"Chromatin; Biology; Transcriptome; SMARCA4; Cell type; Stem cell; Transcription factor; Gene expression; Gene; Progenitor cell; Cell biology; Regulation of gene expression; Cell; Gene expression profiling; Genetics; Computational biology; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008028321,0.00009224319,0.0001445629,0.0002613002,0.0002063154,0.0002190902,0.00009750374,0.0001043798,0.00089269],"category_scores_gemma":[0.0001392997,0.0001121707,0.0001195342,0.00025054,0.0001723407,0.00009409707,0.0001893998,0.0001182568,0.0001879067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475493,"about_ca_system_score_gemma":0.0001753556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00384166,"about_ca_topic_score_gemma":0.01339045,"domain_scores_codex":[0.9999535,0.000002913833,0.000002255444,0.00002091328,0.00001238475,0.00000800314],"domain_scores_gemma":[0.999953,0.00001064037,0.00001090556,0.000007176983,0.000009030285,0.000009230283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003003922,0.000009670551,0.05955163,0.00005896763,0.00003921485,0.0002992128,0.0003912411,0.0004664935,0.9246598,0.0003010587,0.0003829312,0.01353935],"study_design_scores_gemma":[0.0000125067,0.0001070877,0.813762,0.00002050093,0.00006469888,0.001477644,0.0006852601,0.004263582,0.173747,0.0006297191,0.005210359,0.00001952295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915293,0.0004911427,0.004886788,0.00003337075,0.000005034013,0.000007625607,0.00233231,0.00005522329,0.0006590753],"genre_scores_gemma":[0.9916299,0.0003857785,0.00370681,0.0000301719,0.000004044466,0.00001910602,0.003186482,0.00004131052,0.0009964317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00384166,"threshold_uncertainty_score":0.007638633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154560815157003,"score_gpt":0.2175713911992081,"score_spread":0.2021153096835078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}