{"id":"W4220941317","doi":"10.1016/j.celrep.2022.110467","title":"Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council","keywords":"Chromatin; Biology; Transcriptome; SMARCA4; Cell type; Stem cell; Transcription factor; Gene expression; Gene; Progenitor cell; Cell biology; Regulation of gene expression; Cell; Gene expression profiling; Genetics; Computational biology; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004007872,0.0002147723,0.0002932546,0.00005023894,0.0003241591,0.00002822641,0.0001844939,0.0001215509,0.00008290349],"category_scores_gemma":[0.00000573409,0.0002313378,0.0001443139,0.00008747976,0.0001501343,0.00001115696,0.0001852546,0.0001457595,3.967706e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004394463,"about_ca_system_score_gemma":0.00008751176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008894139,"about_ca_topic_score_gemma":0.00002191396,"domain_scores_codex":[0.9981971,0.000104228,0.000561098,0.000588719,0.0002912836,0.0002575273],"domain_scores_gemma":[0.998868,0.000008437197,0.0003446456,0.000596526,0.0000682967,0.0001140436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006276425,0.0003658945,0.003561103,0.0001620685,0.00002149516,0.00009060129,0.0004298315,0.00002130598,0.9944649,0.00002403819,0.000346322,0.0004496925],"study_design_scores_gemma":[0.000497875,0.0007115864,0.005641124,0.000009634459,0.00005989426,0.00008109651,0.0006966537,0.000009401773,0.9894288,0.0003609895,0.002227277,0.0002756995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963482,0.0007171207,0.0002126077,0.00001292219,0.000390972,0.0002890245,0.00004931543,0.00002843097,0.001951399],"genre_scores_gemma":[0.9977514,0.00001204237,0.0004437023,0.00007429156,0.0000480764,0.00001700103,0.0001102923,0.00003700541,0.001506175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005036116,"threshold_uncertainty_score":0.9433681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154560815157003,"score_gpt":0.2175713911992081,"score_spread":0.2021153096835078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}