{"id":"W4220945767","doi":"10.1210/clinem/dgac171","title":"Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization","year":2022,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Instituto de Salud Carlos III; Sixth Framework Programme; Institut Gustave-Roussy; Deutsche Krebshilfe; NordForsk; European Research Council; Hellenic Health Foundation; World Cancer Research Fund; Stavros Niarchos Foundation; Cancerfonden; Hartstichting; Institut National de la Santé et de la Recherche Médicale; Wellcome Trust; Cancer Research UK; World Health Organization; European Commission; Associazione Italiana per la Ricerca sul Cancro; Royal Society; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; European Regional Development Fund; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Dipartimenti di Eccellenza; Freistaat Sachsen; Ministero dell’Istruzione, dell’Università e della Ricerca; British Heart Foundation","keywords":"Mendelian randomization; Coronary heart disease; Mendelian inheritance; Genetics; Internal medicine; Randomization; Biology; Sample (material); Sample size determination; Medicine; Cardiology; Demography; Gene; Randomized controlled trial; Statistics; Genetic variants; Mathematics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07906917,0.001736823,0.003617697,0.001423294,0.0009003866,0.001090846,0.002188042,0.001891498,0.005463074],"category_scores_gemma":[0.1252811,0.001174536,0.004390731,0.001346816,0.001710364,0.00120515,0.001702692,0.001510721,0.0005312109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007403702,"about_ca_system_score_gemma":0.001427202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002983588,"about_ca_topic_score_gemma":0.001824,"domain_scores_codex":[0.8817874,0.1041183,0.002493255,0.007374019,0.00314831,0.00107869],"domain_scores_gemma":[0.9385442,0.03936954,0.004844327,0.01500841,0.001824991,0.0004085225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1502031,0.002950038,0.3968324,0.005234431,0.05556832,0.003565224,0.003639248,0.03882428,0.01331798,0.08311497,0.01172441,0.2350256],"study_design_scores_gemma":[0.04447369,0.03148889,0.1196418,0.001174359,0.04970896,0.004882717,0.0007174381,0.625801,0.007347764,0.09747984,0.01667766,0.0006059469],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5021514,0.002281635,0.4783414,0.0009258035,0.000504958,0.01015953,0.002306395,0.001027734,0.002301317],"genre_scores_gemma":[0.7776609,0.0006283335,0.2033127,0.0004811359,0.0001306732,0.01447807,0.001192862,0.0001619771,0.001953244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07906917,"threshold_uncertainty_score":0.4181627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03086916200549544,"score_gpt":0.3420349477985615,"score_spread":0.3111657857930661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}