{"id":"W4220949287","doi":"10.1021/acssynbio.1c00236","title":"Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation","year":2022,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"NFAT; Chimeric antigen receptor; Cancer research; Antigen; Biology; Reporter gene; T cell; Cell biology; Promoter; Molecular biology; Immunology; Immune system; Gene expression; Gene; Transcription factor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006266984,0.0001951026,0.000351393,0.0002847115,0.0002671335,0.00001974554,0.00008005113,0.0001593964,0.001180737],"category_scores_gemma":[0.0001323248,0.0001729121,0.00008299809,0.000280478,0.0002382464,0.00005865315,0.0003112289,0.0004821636,0.000009719816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892721,"about_ca_system_score_gemma":0.0002283933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005435481,"about_ca_topic_score_gemma":0.000005855016,"domain_scores_codex":[0.998257,0.0002196741,0.0002619551,0.000544392,0.0002275776,0.0004893737],"domain_scores_gemma":[0.9990452,0.0002185268,0.00009745641,0.000427671,0.00009936842,0.0001117986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008085462,0.0001650561,0.001166068,0.0000258204,0.0001061846,0.00003215207,0.0005722198,0.000007011868,0.9797326,0.0001130657,0.00002088507,0.01725038],"study_design_scores_gemma":[0.00359271,0.002664713,0.006967803,0.00005957516,0.0001303285,0.003795671,0.0009191895,0.004934865,0.9425903,0.0004080556,0.03337831,0.0005584662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968976,0.0002218687,0.0002579367,0.001270297,0.0001753866,0.0006455552,0.00003137335,0.00005342804,0.000446517],"genre_scores_gemma":[0.9969215,0.00005974354,0.001300709,0.0004124404,0.0001315741,0.00005513635,0.00003531794,0.00004322278,0.001040287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0371423,"threshold_uncertainty_score":0.9997323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.049114026046286,"score_gpt":0.3148034801829102,"score_spread":0.2656894541366242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}