{"id":"W4220949514","doi":"10.1002/smll.202270050","title":"Targeted Nanoparticle for Co‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2<b>+</b> Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis (Small 11/2022)","year":2022,"lang":"en","type":"article","venue":"Small","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Taxane; Breast cancer; Docetaxel; Drug delivery; Mesoporous silica; Cancer research; Nanoparticle; Medicine; Cancer; Materials science; Oncology; Nanotechnology; Internal medicine; Chemistry; Mesoporous material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009021386,0.0002654078,0.0005777547,0.0001460807,0.0001994111,0.00004443449,0.0002801801,0.00003030656,0.0002641331],"category_scores_gemma":[0.00005514319,0.0002114224,0.00009917255,0.0004466684,0.0002148799,0.0000943308,0.0002021441,0.00006722605,0.000002733715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497626,"about_ca_system_score_gemma":0.0002522067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006255887,"about_ca_topic_score_gemma":0.003523614,"domain_scores_codex":[0.9976714,0.0003546966,0.0005770897,0.0005407581,0.0003417663,0.0005142747],"domain_scores_gemma":[0.9985096,0.0004826757,0.0002672392,0.0004160901,0.0001369225,0.0001874454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002845364,0.0007689321,0.008675241,0.00009607508,0.00004728769,0.00002934055,0.001788606,0.0005311918,0.9787979,0.000084016,0.0002109948,0.006125099],"study_design_scores_gemma":[0.006337139,0.001888948,0.03363445,0.00006654743,0.0001766318,0.0001118518,0.002116527,0.0006298196,0.9529096,0.00005061102,0.001710398,0.0003674284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98795,0.0008917458,0.00001130336,0.003858672,0.0001202535,0.001379272,0.005749739,0.0000350326,0.000003954654],"genre_scores_gemma":[0.998024,0.00003474082,0.001049806,0.0003073944,0.00002239008,0.0004536949,0.00001235596,0.00003751503,0.00005806296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0258882,"threshold_uncertainty_score":0.9457071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881741368202693,"score_gpt":0.2575573291845956,"score_spread":0.2387399155025686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}