{"id":"W4220951323","doi":"10.1101/2022.03.11.483876","title":"<i>In vitro</i> susceptibility to β-lactam antibiotics and viability of <i>Neisseria gonorrhoeae</i> strains producing plasmid-mediated broad- and extended-spectrum β-lactamases","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health of the Russian Federation; Ministry of Science and Higher Education of the Russian Federation; Russian Science Foundation","keywords":"Neisseria gonorrhoeae; Microbiology; Cefotaxime; Plasmid; Cephalosporin; Biology; Ampicillin; Meropenem; Cephaloridine; Antibiotics; Antibiotic resistance; DNA; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004912386,0.0005868194,0.000406841,0.000336607,0.000216897,0.0005092024,0.0003335557,0.0004200131,0.001306326],"category_scores_gemma":[0.0009963589,0.000215742,0.0004014359,0.0003920519,0.0002861428,0.000273573,0.000414127,0.0004630273,0.000446948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00018955,"about_ca_system_score_gemma":0.0001538737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003474098,"about_ca_topic_score_gemma":0.001785837,"domain_scores_codex":[0.9989662,0.0003688822,0.0001549295,0.00016094,0.0002121487,0.0001369452],"domain_scores_gemma":[0.998988,0.000371198,0.0001878411,0.0001096034,0.000262926,0.00008046207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002678689,0.0001507443,0.003065028,0.00007909022,0.00002696525,0.0001090271,0.0001767594,0.0001941463,0.9941323,0.00008416147,0.0001284705,0.001585322],"study_design_scores_gemma":[0.00002018175,0.002552,0.02999933,0.00002336153,0.00006218102,0.0004479049,0.0002554052,0.001169579,0.963617,0.00006276596,0.00175712,0.00003314595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942185,0.0009456298,0.001345714,0.00006638009,0.00002811675,0.00005532961,0.001553056,0.0000362013,0.001751133],"genre_scores_gemma":[0.9862849,0.0007868459,0.003798764,0.00007260377,0.00003163932,0.0001155381,0.007183162,0.00003689887,0.001689742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003474098,"threshold_uncertainty_score":0.006907701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007081192242040303,"score_gpt":0.224799207140829,"score_spread":0.2177180148987887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}