{"id":"W4220953727","doi":"10.1371/journal.pbio.3001592","title":"Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection","year":2022,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; School of Medicine, New York University; National Institute on Drug Abuse; York University; U.S. Public Health Service; BioFire Diagnostics; Burroughs Wellcome Fund; Crohn's and Colitis Foundation of America; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; National Heart, Lung, and Blood Institute; Kenneth Rainin Foundation; Crohn's and Colitis Foundation; Foundation for the National Institutes of Health","keywords":"Organoid; Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Microbiology; 2019-20 coronavirus outbreak; Virology; Cell biology; Infectious disease (medical specialty); Disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003430419,0.0002324939,0.0004112959,0.0002360269,0.0002519887,0.0006187567,0.000156067,0.0002714868,0.001089575],"category_scores_gemma":[0.000416938,0.0001714648,0.0003484393,0.0002138313,0.0002179277,0.0003015314,0.0004172414,0.0006585063,0.0004860151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528375,"about_ca_system_score_gemma":0.0001827341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008422249,"about_ca_topic_score_gemma":0.001313922,"domain_scores_codex":[0.999552,0.0001082355,0.00005633616,0.000118682,0.00009790975,0.00006683611],"domain_scores_gemma":[0.9996593,0.00009099318,0.00005624472,0.00007978883,0.00006738869,0.00004634124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001696588,0.00002048443,0.00214372,0.00003212656,0.00001128798,0.000065099,0.00009473187,0.000067418,0.9966198,0.00002469565,0.000035286,0.0007156812],"study_design_scores_gemma":[0.00001713094,0.001347535,0.1181589,0.00002352602,0.00007190666,0.001029592,0.001080721,0.001886968,0.8725786,0.0001190488,0.003653258,0.00003275113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904932,0.001346358,0.005462377,0.00008088804,0.000038652,0.00007254761,0.000968441,0.00005996414,0.001477608],"genre_scores_gemma":[0.9930297,0.0006802758,0.003244958,0.00009944358,0.000009546078,0.00008996505,0.001855844,0.00001988432,0.0009703476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089575,"threshold_uncertainty_score":0.003645003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04140205375328455,"score_gpt":0.2979285489461106,"score_spread":0.2565264951928261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}