{"id":"W4220954100","doi":"10.1073/pnas.2113074119","title":"Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"West China Hospital, Sichuan University; Lee Kong Chian School of Medicine, Nanyang Technological University; Institute of Molecular and Cell Biology; Horizon 2020; Innovative Medicines Initiative; Novo Nordisk Fonden; National Natural Science Foundation of China; Vetenskapsrådet; Agency for Science, Technology and Research; Novo Nordisk; Servier; Karolinska Institutet; Nanyang Technological University; Singapore General Hospital; Singapore Eye Research Institute; National Research Foundation Singapore; National Research Foundation; National University of Singapore; Diabetes Research and Wellness Foundation; Ministry of Education - Singapore; European Commission; Sichuan University; Ministry of Education, India; Stichting af Jochnick Foundation; Directorate for Biological Sciences; Imperial College London; Medical Research Council; Genome Institute of Singapore; Wellcome Trust","keywords":"Intracellular; Endoplasmic reticulum; Unfolded protein response; Biogenesis; Internal medicine; Endocrinology; Lipotoxicity; Lipid droplet; Chemistry; Diabetes mellitus; Secretion; Cell biology; Biochemistry; Biology; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836705,0.0003713277,0.0002752715,0.0001829295,0.0001872342,0.000443438,0.0001619655,0.0003662821,0.002346331],"category_scores_gemma":[0.0001398974,0.000149922,0.0003128773,0.0001390679,0.0002379867,0.0003310655,0.0003810995,0.000656742,0.0004414789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000286681,"about_ca_system_score_gemma":0.0001564255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003451979,"about_ca_topic_score_gemma":0.000523352,"domain_scores_codex":[0.9998935,0.00002085932,0.00001452256,0.00002203108,0.00002140835,0.00002758845],"domain_scores_gemma":[0.9998477,0.00001761647,0.0000414124,0.00002110162,0.00002018433,0.00005209449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004418373,0.00002229456,0.0005418659,0.00002535474,0.00001149138,0.00005153794,0.00001004063,0.00003476735,0.9979256,0.0001008787,0.00004733733,0.0007868775],"study_design_scores_gemma":[0.00005170945,0.0003281157,0.01007606,0.000009811218,0.00004196162,0.000471369,0.00009415999,0.0006548439,0.9845024,0.0002571434,0.003503099,0.000009195776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925867,0.002573786,0.00269168,0.0003429621,0.00007943979,0.00001857019,0.0004040068,0.00006763264,0.001235303],"genre_scores_gemma":[0.9938158,0.001252203,0.001465724,0.0002148807,0.00001835998,0.00002497102,0.0003937864,0.0000368011,0.002777473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002346331,"threshold_uncertainty_score":0.007849276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009402760965290793,"score_gpt":0.2393930455617783,"score_spread":0.2299902845964875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}