{"id":"W4220956838","doi":"10.1016/j.molmet.2022.101463","title":"Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction","year":2022,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Epigenome; Biology; Epigenetics; H3K4me3; Genetics; Histone methylation; Histone; Demethylase; Offspring; Histone H3; Histone methyltransferase; DNA methylation; Endocrinology; Pregnancy; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007171575,0.0002335041,0.0004624546,0.0001121791,0.0001733199,0.00001728141,0.000194748,0.00007817138,0.0000469713],"category_scores_gemma":[0.000127037,0.0001888186,0.00015838,0.0004328046,0.0001505818,0.0000111508,0.0001603142,0.0001694113,7.337365e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001008416,"about_ca_system_score_gemma":0.00008017068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002267189,"about_ca_topic_score_gemma":0.00003231469,"domain_scores_codex":[0.9979717,0.0005102191,0.0003991369,0.0004002963,0.0004995475,0.0002191513],"domain_scores_gemma":[0.9986842,0.00002626141,0.0005067874,0.0004461799,0.0002719854,0.00006459561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001840449,0.0001554408,0.003993889,0.0000149191,0.0003515175,0.000004004855,0.0003221432,0.000590833,0.9920182,0.0005530035,0.00002196932,0.001789998],"study_design_scores_gemma":[0.001224347,0.0002007347,0.1243434,0.000006821082,0.0003999501,0.000008706465,0.000127943,0.0001184349,0.85716,0.0003214701,0.01587756,0.0002106629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9487705,0.04844111,0.001861914,0.000228952,0.0001392297,0.0003219807,0.00008995266,0.000008573845,0.0001377807],"genre_scores_gemma":[0.9975373,0.001116349,0.0004234408,0.0002010004,0.00006957186,0.00004268617,0.0001170258,0.00003645913,0.0004562171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1348583,"threshold_uncertainty_score":0.7699801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007356201708859996,"score_gpt":0.2300909233376263,"score_spread":0.2227347216287663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}