{"id":"W4220959221","doi":"10.1111/iju.14843","title":"Safety and efficacy of apalutamide in Japanese patients with metastatic castration‐sensitive prostate cancer receiving androgen deprivation therapy: Final report for the Japanese subpopulation analysis of the randomized, placebo‐controlled, phase III TITAN study","year":2022,"lang":"en","type":"article","venue":"International Journal of Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure","funders":"Janssen Research and Development","keywords":"Medicine; Placebo; Interim analysis; Hazard ratio; Prostate cancer; Internal medicine; Population; Randomized controlled trial; Oncology; Cancer; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005020723,0.0008416926,0.002369384,0.0002613625,0.0004643241,0.0006409416,0.0004811036,0.0009359006,0.001293526],"category_scores_gemma":[0.003029432,0.0004396176,0.002604707,0.0003144994,0.0005672924,0.0004135011,0.000271566,0.0009025928,0.0002168937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004848969,"about_ca_system_score_gemma":0.001473354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136763,"about_ca_topic_score_gemma":0.002685993,"domain_scores_codex":[0.9983853,0.001025619,0.000179306,0.0001412042,0.0001752396,0.00009331317],"domain_scores_gemma":[0.9978998,0.0004241698,0.0007480183,0.0002821579,0.0003522573,0.0002936497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.858717,0.004877015,0.01909616,0.002525507,0.009943447,0.0003034226,0.0005413158,0.0008605027,0.025288,0.0001681464,0.002073514,0.07560593],"study_design_scores_gemma":[0.5804489,0.2720424,0.1153841,0.0002332604,0.01867372,0.0005656668,0.0002049574,0.001202006,0.005919147,0.0002513389,0.004951073,0.0001233525],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904549,0.005634315,0.0006424303,0.0003183839,0.00007827367,0.001343639,0.0005894272,0.00003950426,0.000899127],"genre_scores_gemma":[0.9929671,0.002330139,0.001190698,0.0005350138,0.0001990709,0.001263472,0.0008642445,0.000016743,0.0006334648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005020723,"threshold_uncertainty_score":0.02655244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443639978469364,"score_gpt":0.3465550265580264,"score_spread":0.3221186267733328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}