{"id":"W4220959221","doi":"10.1111/iju.14843","title":"Safety and efficacy of apalutamide in Japanese patients with metastatic castration‐sensitive prostate cancer receiving androgen deprivation therapy: Final report for the Japanese subpopulation analysis of the randomized, placebo‐controlled, phase III TITAN study","year":2022,"lang":"en","type":"article","venue":"International Journal of Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure","funders":"Janssen Research and Development","keywords":"Medicine; Placebo; Interim analysis; Hazard ratio; Prostate cancer; Internal medicine; Population; Randomized controlled trial; Oncology; Cancer; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001741239,0.00009931227,0.000644898,0.0003715242,0.00008506086,0.000009071458,0.0001170582,0.0000174455,0.00002262964],"category_scores_gemma":[0.0004715348,0.00005010165,0.0001730012,0.0003347562,0.0001308151,0.00007989931,0.00003785667,0.0001698521,1.469734e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000145438,"about_ca_system_score_gemma":0.0001930984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000571711,"about_ca_topic_score_gemma":0.0004686081,"domain_scores_codex":[0.9978872,0.000450957,0.0008142431,0.0001375274,0.0006127271,0.00009733599],"domain_scores_gemma":[0.9968354,0.001107279,0.001098302,0.000113342,0.0008192033,0.0000264697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6789748,0.001183355,0.2779832,0.00000607504,0.009056458,0.00005584032,0.007830496,0.02242803,0.0002612559,0.00001396321,0.000002575537,0.002203855],"study_design_scores_gemma":[0.4858016,0.001405793,0.4993061,0.00001971333,0.002750558,0.0001182873,0.001672604,0.008758314,0.00006556613,0.00003781423,0.00001174282,0.00005198444],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954278,0.0004247309,0.0001267737,0.00137845,0.000128345,0.002442217,0.00005826198,0.000001433685,0.0000119338],"genre_scores_gemma":[0.9995036,0.00012381,0.00002522595,0.00004913427,0.00002655599,0.0001327849,0.00007195846,0.000007904974,0.00005906315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2213228,"threshold_uncertainty_score":0.2043086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443639978469364,"score_gpt":0.3465550265580264,"score_spread":0.3221186267733328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}