{"id":"W4220960592","doi":"10.1016/j.celrep.2021.110232","title":"Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neural dynamics and brain function","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Centre for Addiction and Mental Health","funders":"Krembil Foundation; Centre for Addiction and Mental Health Foundation; Kavli Foundation","keywords":"Neuroscience; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Stimulus (psychology); Human brain; Somatostatin; Psychology; Premovement neuronal activity; Interneuron; Cognition; Electrophysiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003385055,0.0001067824,0.0001309951,0.0001804831,0.0003470048,0.00005245693,0.00004767488,0.0000426801,0.00006403738],"category_scores_gemma":[0.0001434808,0.0001114688,0.00003559784,0.0004582032,0.00004337607,0.0001458849,0.0001264118,0.0004062,0.00000161157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001974329,"about_ca_system_score_gemma":0.00007807201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004338245,"about_ca_topic_score_gemma":0.00001722021,"domain_scores_codex":[0.9983525,0.0001363579,0.0004320386,0.0005232509,0.0002935142,0.0002623886],"domain_scores_gemma":[0.9995321,0.0000356162,0.0001923215,0.0001719365,0.00001317077,0.00005483662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001196502,0.0001982214,0.0074254,0.00002128279,8.967174e-8,0.002692984,0.0002062436,0.001806793,0.985402,0.000007590143,0.00006274477,0.002164615],"study_design_scores_gemma":[0.0005425834,0.000132149,0.04522837,0.00005747084,0.000004421607,0.001016483,0.0001324664,0.008555325,0.9425814,0.001177674,0.0003080098,0.0002636588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972696,0.00002875196,0.00003220759,0.00004097063,0.0002791363,0.000281208,0.000001083484,0.00005099063,0.002016048],"genre_scores_gemma":[0.9993697,0.000001673277,0.000007215175,0.0001962025,0.00002326043,0.00005595887,0.00001364692,0.00001809743,0.0003141803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04282068,"threshold_uncertainty_score":0.4545568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0213215128832926,"score_gpt":0.2629517061949345,"score_spread":0.2416301933116419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}