{"id":"W4220960592","doi":"10.1016/j.celrep.2021.110232","title":"Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neural dynamics and brain function","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Centre for Addiction and Mental Health","funders":"Krembil Foundation; Centre for Addiction and Mental Health Foundation; Kavli Foundation","keywords":"Neuroscience; Inhibitory postsynaptic potential; Excitatory postsynaptic potential; Stimulus (psychology); Human brain; Somatostatin; Psychology; Premovement neuronal activity; Interneuron; Cognition; Electrophysiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008817671,0.0002123378,0.0001653235,0.00009989097,0.00007915646,0.0002725,0.0002824795,0.0002651977,0.0005098337],"category_scores_gemma":[0.0004440427,0.0001297648,0.0002287805,0.0001010362,0.0001988152,0.0001153903,0.0001317853,0.0001557401,0.00004834712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004431395,"about_ca_system_score_gemma":0.0003541209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0113315,"about_ca_topic_score_gemma":0.008003074,"domain_scores_codex":[0.9999529,0.0000122189,0.000001763244,0.00001271312,0.00001041759,0.000009959055],"domain_scores_gemma":[0.9998888,0.00006551428,0.00001815832,0.000008769518,0.00001053784,0.000008273551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001398085,0.00007713012,0.00647396,0.00004603055,0.00004561971,0.0002197216,0.00007071482,0.9377517,0.04837453,0.001420954,0.0002023597,0.005177363],"study_design_scores_gemma":[0.0000133098,0.00008677631,0.003671006,0.00000239107,0.00001141777,0.00004846652,0.00001444013,0.9880998,0.007401851,0.000513888,0.0001309224,0.000005764663],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976256,0.00005860566,0.02238046,0.00007626034,0.000005648677,0.0000158132,0.0001945624,0.00008466817,0.0009280141],"genre_scores_gemma":[0.9969606,0.00004875005,0.002648574,0.00001212207,7.939831e-7,0.00001570769,0.00005842529,0.000005050825,0.0002499493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0113315,"threshold_uncertainty_score":0.02253109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0213215128832926,"score_gpt":0.2629517061949345,"score_spread":0.2416301933116419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}