{"id":"W4220961745","doi":"10.1158/1538-7445.sabcs21-p5-13-36","title":"Abstract P5-13-36: Germline <i>BRCA</i>1/2 and other predisposition genes in high-risk early-stage HR+/HER2- breast cancer (BC) patients treated with endocrine therapy (ET) with or without palbociclib: A secondary analysis from the PENELOPE-B study","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"CHEK2; Medicine; Oncology; Internal medicine; Breast cancer; PALB2; Cancer; Germline; Hazard ratio; Germline mutation; Genetics; Mutation; Biology; Gene; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007685492,0.0004275638,0.0005793405,0.0004432508,0.0003257332,0.0005658967,0.0004244919,0.0004460929,0.004644614],"category_scores_gemma":[0.001046186,0.0002200818,0.001254075,0.0006267324,0.0002760726,0.0002524292,0.0003523116,0.0007769309,0.000511913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549847,"about_ca_system_score_gemma":0.0003927153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002547194,"about_ca_topic_score_gemma":0.003033543,"domain_scores_codex":[0.9994438,0.0001818849,0.00004887273,0.0001804695,0.00007658901,0.00006835844],"domain_scores_gemma":[0.9989443,0.0002509679,0.0003337352,0.0001394501,0.00008771539,0.0002437487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0675276,0.001450466,0.9034036,0.0003448045,0.003458764,0.0006727875,0.0001286807,0.0003473196,0.00729818,0.00009974924,0.004670209,0.01059773],"study_design_scores_gemma":[0.00619143,0.004542686,0.9841353,0.00002539585,0.001456367,0.0005295913,0.0000695702,0.0004120395,0.001010803,0.00007209389,0.001540812,0.00001386552],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933921,0.0003471666,0.0001528294,0.0000715205,0.00001235287,0.0001124375,0.005403214,0.00001032154,0.0004981685],"genre_scores_gemma":[0.9929681,0.00007348766,0.00009928097,0.0001345468,0.00002725292,0.00008720619,0.006097401,0.000005870208,0.0005067951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004644614,"threshold_uncertainty_score":0.01553774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03400871225458401,"score_gpt":0.3600987525816422,"score_spread":0.3260900403270582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}