{"id":"W4220961745","doi":"10.1158/1538-7445.sabcs21-p5-13-36","title":"Abstract P5-13-36: Germline <i>BRCA</i>1/2 and other predisposition genes in high-risk early-stage HR+/HER2- breast cancer (BC) patients treated with endocrine therapy (ET) with or without palbociclib: A secondary analysis from the PENELOPE-B study","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"CHEK2; Medicine; Oncology; Internal medicine; Breast cancer; PALB2; Cancer; Germline; Hazard ratio; Germline mutation; Genetics; Mutation; Biology; Gene; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007160738,0.0004647946,0.0008214943,0.0004512509,0.0005502923,0.0001166221,0.0003816084,0.00005978176,0.004223214],"category_scores_gemma":[0.00001251211,0.0002660318,0.00008083436,0.002323662,0.0004046649,0.0002891895,0.0001930996,0.001308369,0.000002904945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007285317,"about_ca_system_score_gemma":0.0007880806,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2971634,"about_ca_topic_score_gemma":0.1372879,"domain_scores_codex":[0.9953817,0.0007815801,0.0004710587,0.00105299,0.00153824,0.0007744911],"domain_scores_gemma":[0.9978896,0.0003345953,0.000274266,0.0008187839,0.0004564665,0.0002263278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03962599,0.001066684,0.9221398,0.00003574793,0.002396726,0.0001431313,0.004971493,0.001421156,0.0005929907,0.000001326069,0.0000368209,0.02756818],"study_design_scores_gemma":[0.01825344,0.002282316,0.973,0.0001474745,0.0003930968,0.00001393774,0.003493379,0.00009503257,0.0005994905,0.000009580911,0.00136775,0.0003444566],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907588,0.002201729,0.00001548637,0.0009108062,0.00004123241,0.003040965,0.00290075,0.00007793443,0.00005230671],"genre_scores_gemma":[0.9930078,0.001365347,0.00007633718,0.0004694554,0.0002058107,0.00375939,0.0001818683,0.0001622447,0.0007717959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1598756,"threshold_uncertainty_score":0.9999792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03400871225458401,"score_gpt":0.3600987525816422,"score_spread":0.3260900403270582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}