{"id":"W4220963583","doi":"10.3324/haematol.2021.279756","title":"The glycolytic enzyme PFKFB3 determines bone marrow endothelial progenitor cell damage after chemotherapy and irradiation","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; School of Medicine, Shanghai Jiao Tong University; Peking University; Shanghai Jiao Tong University; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences","keywords":"Haematopoiesis; Cancer research; Bone marrow; Progenitor cell; Stem cell; Endothelial stem cell; Chemistry; In vivo; Cell biology; Biology; In vitro; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008527442,0.000177658,0.0001437131,0.0002301703,0.000114795,0.0001618278,0.00005977917,0.0001772733,0.000682076],"category_scores_gemma":[0.00009733903,0.0001056107,0.000140437,0.000182383,0.0001640368,0.0001146454,0.0001457308,0.0003360353,0.0001210234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000214043,"about_ca_system_score_gemma":0.00009997188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004693976,"about_ca_topic_score_gemma":0.0004661575,"domain_scores_codex":[0.9999241,0.000009517053,0.000006384842,0.00001934415,0.00001568262,0.00002495624],"domain_scores_gemma":[0.9999527,0.000003333474,0.00002315858,0.000002886427,0.000004464876,0.00001357474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005680269,0.00002184324,0.005033992,0.00003844628,0.00001296405,0.0001081798,0.00002552185,0.00006831394,0.9914553,0.00005788762,0.00005555982,0.002553981],"study_design_scores_gemma":[0.00005681891,0.0006539096,0.1857783,0.00001846307,0.00008468521,0.001734336,0.00009051288,0.00104744,0.80779,0.000198688,0.00253738,0.000009519702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975954,0.001144703,0.0006770907,0.00003079047,0.000004763569,0.00001343272,0.0001822504,0.00001867526,0.0003328604],"genre_scores_gemma":[0.998792,0.0004026154,0.0002281189,0.00001881674,0.000002201032,0.00001202094,0.0002190833,0.000003514932,0.000321682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000682076,"threshold_uncertainty_score":0.002281785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005893512811003071,"score_gpt":0.2133466337711242,"score_spread":0.2074531209601212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}