{"id":"W4220963583","doi":"10.3324/haematol.2021.279756","title":"The glycolytic enzyme PFKFB3 determines bone marrow endothelial progenitor cell damage after chemotherapy and irradiation","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; School of Medicine, Shanghai Jiao Tong University; Peking University; Shanghai Jiao Tong University; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences","keywords":"Haematopoiesis; Cancer research; Bone marrow; Progenitor cell; Stem cell; Endothelial stem cell; Chemistry; In vivo; Cell biology; Biology; In vitro; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705163,0.0001590757,0.0001791798,0.00002536352,0.0003340127,0.00004619619,0.0001706524,0.00007805702,0.00009106042],"category_scores_gemma":[0.00003097512,0.0001180448,0.00008596326,0.00006504334,0.0001080987,0.000004182215,0.0001481438,0.0001010972,0.000005524952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001166966,"about_ca_system_score_gemma":0.00005238733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008953258,"about_ca_topic_score_gemma":0.00002301978,"domain_scores_codex":[0.9989809,0.0001047425,0.0001871813,0.0003188137,0.0001429043,0.0002654882],"domain_scores_gemma":[0.9994749,0.00002502768,0.0001035925,0.0003021218,0.00002978885,0.00006458868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00132347,0.000160781,0.002300889,0.00005674807,0.00005780517,0.00004070866,0.0003165587,0.00001026231,0.9689767,0.0001372205,0.01290393,0.01371486],"study_design_scores_gemma":[0.001222126,0.0003126554,0.004113928,0.000002719026,0.00003543115,0.0003529603,0.0001660127,0.00008299858,0.123989,0.0001558058,0.8692958,0.0002705228],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869475,0.01105925,0.0000299363,0.0004264115,0.0007024347,0.0004084545,0.00005175248,0.00002173871,0.0003525616],"genre_scores_gemma":[0.994524,0.001313494,0.0002455918,0.0007105501,0.0006485647,0.00048969,0.0000275769,0.00002312309,0.002017414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8563919,"threshold_uncertainty_score":0.4813726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005893512811003071,"score_gpt":0.2133466337711242,"score_spread":0.2074531209601212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}