{"id":"W4220964905","doi":"10.3389/fradi.2022.782864","title":"Sex Differences in the Metabolome of Alzheimer's Disease Progression","year":2022,"lang":"en","type":"article","venue":"Frontiers in Radiology","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institute of Food and Agriculture; National Institutes of Health; Genentech; IXICO; Social Science Research Institute, Pennsylvania State University; H. Lundbeck A/S; National Cancer Institute; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; BioClinica; Pfizer; Biogen; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; U.S. Department of Agriculture; Foundation for the National Institutes of Health","keywords":"Metabolomics; Metabolite; Metabolome; Neuroimaging; Disease; Biology; Dementia; Neurology; Internal medicine; Phenotype; Bioinformatics; Physiology; Neuroscience; Psychology; Medicine; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005247829,0.0001112677,0.0003098242,0.0001411884,0.00007286022,0.000003244651,0.0003439365,0.00004539097,0.00001772361],"category_scores_gemma":[0.00006542476,0.00007977986,0.00006904654,0.0002114035,0.0001603504,0.000001788859,0.0001887479,0.000152061,1.707678e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000100912,"about_ca_system_score_gemma":0.00004207395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000011383,"about_ca_topic_score_gemma":0.000005546588,"domain_scores_codex":[0.998704,0.0004490013,0.0002336069,0.0002709983,0.000115896,0.0002265265],"domain_scores_gemma":[0.9995864,0.00001736272,0.00009792686,0.0002607874,0.00001015587,0.00002735485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002741936,0.0002849208,0.9683427,0.00001255076,0.0001885806,0.0000224082,0.0005114959,0.0001086725,0.01256709,0.001174051,0.01062484,0.005888538],"study_design_scores_gemma":[0.00199356,0.001064439,0.8968956,0.000007911974,0.0001369957,0.00003366859,0.004206094,0.000455601,0.004261161,0.00473401,0.08574886,0.000462106],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9428422,0.05512954,0.0002628057,0.0004835071,0.0006002131,0.0002787852,0.00003655687,0.000003126237,0.000363212],"genre_scores_gemma":[0.9970307,0.001486768,0.0009555919,0.000170915,0.00005922134,0.0001846411,0.0000496446,0.000007320747,0.00005519728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07512402,"threshold_uncertainty_score":0.3253328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314759764921672,"score_gpt":0.2536733588576198,"score_spread":0.2405257612084031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}