{"id":"W4220964905","doi":"10.3389/fradi.2022.782864","title":"Sex Differences in the Metabolome of Alzheimer's Disease Progression","year":2022,"lang":"en","type":"article","venue":"Frontiers in Radiology","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institute of Food and Agriculture; National Institutes of Health; Genentech; IXICO; Social Science Research Institute, Pennsylvania State University; H. Lundbeck A/S; National Cancer Institute; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; BioClinica; Pfizer; Biogen; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; U.S. Department of Agriculture; Foundation for the National Institutes of Health","keywords":"Metabolomics; Metabolite; Metabolome; Neuroimaging; Disease; Biology; Dementia; Neurology; Internal medicine; Phenotype; Bioinformatics; Physiology; Neuroscience; Psychology; Medicine; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006879217,0.0004130668,0.0003665003,0.000632452,0.0002157124,0.0006545827,0.0001434633,0.0002347387,0.001506637],"category_scores_gemma":[0.001319591,0.000151607,0.0005922692,0.0006347815,0.0002052042,0.0002353949,0.0004094562,0.0002597381,0.0002216853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001348569,"about_ca_system_score_gemma":0.000176733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001817698,"about_ca_topic_score_gemma":0.00243587,"domain_scores_codex":[0.9996997,0.00007509386,0.00002285446,0.0001116197,0.00005079496,0.00003998388],"domain_scores_gemma":[0.9996789,0.00008673703,0.00009514351,0.00005968181,0.00005193669,0.00002766208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002418818,0.00008094902,0.8608224,0.0002755359,0.001477149,0.0003953467,0.0005944615,0.001002604,0.07146212,0.0005963679,0.001274662,0.0595997],"study_design_scores_gemma":[0.00001284427,0.0001485879,0.9919747,0.00001787177,0.0002338902,0.0003567041,0.0001152109,0.0008109022,0.004101831,0.0007055567,0.001505842,0.00001611923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882798,0.002704825,0.003388243,0.0001611979,0.00003551531,0.00002697589,0.004010314,0.00006494797,0.001328229],"genre_scores_gemma":[0.9944116,0.0006922183,0.002092647,0.0001131036,0.00001907339,0.00003179336,0.00194171,0.00003489534,0.0006628569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001817698,"threshold_uncertainty_score":0.005040169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314759764921672,"score_gpt":0.2536733588576198,"score_spread":0.2405257612084031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}