{"id":"W4220966499","doi":"10.1213/ane.0000000000005935","title":"The Future of Clinical Trials Methodology: Accomplishments and Challenges Ahead","year":2022,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Clinical trial; Pandemic; Anesthesiology; Randomized controlled trial; Psychological intervention; Protocol (science); Clinical research; Clinical Practice","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7855999,0.005178153,0.01224412,0.01659851,0.005637643,0.0294764,0.01784978,0.0311664,0.00988538],"category_scores_gemma":[0.7537932,0.004205661,0.006996006,0.01238941,0.08923683,0.05750886,0.0184594,0.06555112,0.006271578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01826236,"about_ca_system_score_gemma":0.05423272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004586027,"about_ca_topic_score_gemma":0.003874763,"domain_scores_codex":[0.3175533,0.5664607,0.0389812,0.01473357,0.05958348,0.002687763],"domain_scores_gemma":[0.05877448,0.8386869,0.009009775,0.0330798,0.05277996,0.007668971],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009036373,0.0003437608,0.001535954,0.01132458,0.0008379778,0.0002244173,0.002987821,0.001753711,0.0002198402,0.3433386,0.2305554,0.4059743],"study_design_scores_gemma":[0.0008485083,0.0009630303,0.001217549,0.03025571,0.0003273213,0.0004331713,0.002082451,0.007111793,0.0002610853,0.5557831,0.4002463,0.0004699382],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.000312137,0.2422882,0.06991801,0.6410444,0.04178396,0.0007656585,0.0002359951,0.0005668327,0.003084833],"genre_scores_gemma":[0.02425132,0.1964821,0.3734141,0.2233814,0.1723561,0.005811086,0.0005130334,0.001235923,0.00255513],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.2144001,"threshold_uncertainty_score":0.2643935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7716812091128887,"score_gpt":0.5482927457618799,"score_spread":0.2233884633510088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}