{"id":"W4220967035","doi":"10.21203/rs.3.rs-1420033/v1","title":"Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Medical Research Council","keywords":"Translocator protein; Microglia; Rodent; Rodent model; Neuroscience; Biology; Medicine; Inflammation; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003856463,0.0006764689,0.0006018316,0.001066887,0.0003837807,0.0007956806,0.0002271008,0.001015261,0.005121639],"category_scores_gemma":[0.0005952428,0.0002364546,0.0003251961,0.0006257431,0.0006971499,0.0007556339,0.0005142083,0.0007727079,0.001306609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499579,"about_ca_system_score_gemma":0.0002502407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002241243,"about_ca_topic_score_gemma":0.0003258068,"domain_scores_codex":[0.999668,0.00003544568,0.00002425036,0.0001035718,0.00009228098,0.00007659195],"domain_scores_gemma":[0.9995296,0.00004139228,0.0002234945,0.00004830588,0.00007207068,0.00008509464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0010427,0.00006232975,0.002079446,0.000205662,0.00004055561,0.0008227024,0.0001157823,0.00006159717,0.9900264,0.0007967585,0.0007416138,0.004004447],"study_design_scores_gemma":[0.0001968838,0.00100732,0.08787762,0.0001420937,0.0002168136,0.01651231,0.0006675196,0.001243432,0.8660986,0.005110298,0.0208839,0.00004321072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750578,0.007274304,0.009763301,0.001248546,0.0003840977,0.00003582633,0.001601486,0.0003766178,0.004258024],"genre_scores_gemma":[0.9700609,0.003928038,0.009357207,0.0003021242,0.0002143262,0.00009510368,0.003877241,0.0003237272,0.01184139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005121639,"threshold_uncertainty_score":0.01713359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1272198758643579,"score_gpt":0.380809940418721,"score_spread":0.2535900645543631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}