{"id":"W4220969069","doi":"10.1139/cjc-2021-0290","title":"An efficient synthesis of substituted hexahydrobenzo[<i>f</i>]thieno[<i>c</i>]quinoline; an advanced intermediate of analog of A-86929, a dopamine D1 full agonist","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Chemistry; Friedel–Crafts reaction; Yield (engineering); Catalysis; Quinoline; Combinatorial chemistry; Agonist; Medicinal chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393203,0.0003840372,0.0003069382,0.0001649912,0.0001870993,0.0001382155,0.0004533112,0.0002636324,0.002023488],"category_scores_gemma":[0.00008577886,0.0001566633,0.0001676742,0.0002233218,0.0001323692,0.0002126461,0.0002391689,0.0003844925,0.0006571067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002451137,"about_ca_system_score_gemma":0.0003740571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001105898,"about_ca_topic_score_gemma":0.002238553,"domain_scores_codex":[0.999907,0.000009893934,0.000009423973,0.00002302869,0.00001769653,0.00003295828],"domain_scores_gemma":[0.9999597,0.000003068233,0.000008369843,0.000005375158,0.00000875975,0.00001485006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001665051,0.00009816627,0.0001744967,0.0003764144,0.00002150313,0.0006799938,0.000169003,0.0009283044,0.9808816,0.001949928,0.0005642559,0.01398991],"study_design_scores_gemma":[0.00009870531,0.001178085,0.00167891,0.00002121821,0.00004847539,0.001124144,0.00005520595,0.001832104,0.9739549,0.0003755114,0.01958859,0.00004415856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8907994,0.007596559,0.06734473,0.0003403095,0.0002295009,0.0005553564,0.002858921,0.0005262344,0.02974901],"genre_scores_gemma":[0.9834373,0.002437993,0.009285237,0.00004027609,0.00001161046,0.00006076058,0.0005049174,0.00002854676,0.00419343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023488,"threshold_uncertainty_score":0.00676924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007727216925923129,"score_gpt":0.2162517538002501,"score_spread":0.208524536874327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}