{"id":"W4220969069","doi":"10.1139/cjc-2021-0290","title":"An efficient synthesis of substituted hexahydrobenzo[<i>f</i>]thieno[<i>c</i>]quinoline; an advanced intermediate of analog of A-86929, a dopamine D1 full agonist","year":2022,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Chemistry; Friedel–Crafts reaction; Yield (engineering); Catalysis; Quinoline; Combinatorial chemistry; Agonist; Medicinal chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000461179,0.0002736979,0.0007861433,0.000241972,0.0001541475,0.00002151879,0.001003575,0.0001300435,0.001929671],"category_scores_gemma":[0.0004062706,0.0002882886,0.0003523241,0.0004238627,0.0004251094,0.0001336924,0.00004488754,0.0004725835,7.414175e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003322871,"about_ca_system_score_gemma":0.001666208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010591,"about_ca_topic_score_gemma":0.0005708042,"domain_scores_codex":[0.9974233,0.00004588029,0.001298283,0.0002968177,0.0005247826,0.0004109592],"domain_scores_gemma":[0.9963892,0.0001694496,0.001543412,0.0006865273,0.000427691,0.0007837474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190426,0.0003746719,0.0006790648,0.0003573699,0.0001605656,0.0001218918,0.0003991745,0.006585862,0.9876378,0.00001567819,0.00005694752,0.003420614],"study_design_scores_gemma":[0.0006706187,0.0001040375,0.0004726554,0.0002497422,0.0001871102,0.0005780817,0.00296337,0.0005685554,0.9926553,0.00002487623,0.001255497,0.0002701768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951724,0.0006881735,0.00003207553,0.0000667658,0.0001414535,0.00005078307,0.0008026972,0.000009832166,0.003035854],"genre_scores_gemma":[0.9994462,0.00003866931,0.0001747771,0.00001298229,0.0001427757,0.00001161709,0.00006563853,0.00004136937,0.00006596437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006017307,"threshold_uncertainty_score":0.9999569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007727216925923129,"score_gpt":0.2162517538002501,"score_spread":0.208524536874327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}