{"id":"W4220969080","doi":"10.3390/cancers14061580","title":"Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"CTLA-4; Priming (agriculture); Immunology; Cytotoxic T cell; CD80; Immunotherapy; Effector; Medicine; Immune system; Cancer immunotherapy; T cell; Tumor microenvironment; Cancer research; Biology; CD40; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001484728,0.0004783752,0.001139406,0.0005586708,0.0002625565,0.001158087,0.0007553678,0.001908004,0.003261143],"category_scores_gemma":[0.0007254535,0.0001607419,0.0006924965,0.0004556652,0.0009400519,0.003006202,0.0007891711,0.004009433,0.0009107245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006008604,"about_ca_system_score_gemma":0.0009109387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000226276,"about_ca_topic_score_gemma":0.0006220162,"domain_scores_codex":[0.9996476,0.0001141198,0.00004374681,0.00005717141,0.00008558041,0.0000517821],"domain_scores_gemma":[0.9997354,0.0001340754,0.00004264019,0.000008205512,0.00004445293,0.00003521503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00105881,0.0003897334,0.0005802967,0.0130805,0.00021492,0.0008619633,0.0003076312,0.0004330582,0.01968573,0.03113371,0.05197246,0.8802812],"study_design_scores_gemma":[0.0004192832,0.001930269,0.001577329,0.005181149,0.000258479,0.002893428,0.0004011144,0.0007336228,0.00571145,0.02014449,0.9606918,0.00005758828],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001879127,0.980781,0.0009101496,0.01147634,0.002614317,0.00002280052,0.00002188115,0.00002437164,0.002270135],"genre_scores_gemma":[0.01193487,0.9681603,0.001272529,0.01044326,0.003834408,0.00006186641,0.00005031075,0.00001557562,0.004226959],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003261143,"threshold_uncertainty_score":0.01090962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1050909900318455,"score_gpt":0.3548163337466503,"score_spread":0.2497253437148048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}