{"id":"W4220969484","doi":"10.1007/s40097-022-00487-0","title":"Double-grafted chitosans as siRNA nanocarriers: effects of diisopropylethylamine substitution and labile-PEG coating","year":2022,"lang":"en","type":"article","venue":"Journal of nanostructure in chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Nanocarriers; HeLa; Polyethylene glycol; Small interfering RNA; Nanochemistry; Chitosan; Lipofectamine; PEG ratio; Gene knockdown; Chemistry; Nanoparticle; Biophysics; Conjugated system; PEGylation; Combinatorial chemistry; Polymer; Transfection; Materials science; Nanotechnology; In vitro; Organic chemistry; Biochemistry; Recombinant DNA; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341914,0.0004070722,0.0002501725,0.0002084301,0.0001567681,0.0002915057,0.0002558207,0.0003611462,0.0009331675],"category_scores_gemma":[0.0003050149,0.000208854,0.0002364154,0.0002127964,0.0002614988,0.0002547585,0.0001568404,0.0003618897,0.0002194035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600618,"about_ca_system_score_gemma":0.0004316503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00372382,"about_ca_topic_score_gemma":0.004598261,"domain_scores_codex":[0.9998235,0.00002033957,0.00002401059,0.00004110677,0.00004430858,0.0000467437],"domain_scores_gemma":[0.9998015,0.0000431833,0.00005131147,0.00001794115,0.00004436481,0.00004175569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001237132,0.00001095836,0.00002537335,0.00002420525,0.000004677965,0.00001972122,0.000008860446,0.00006056991,0.9991379,0.00003677028,0.00001601243,0.0005311626],"study_design_scores_gemma":[0.000007783923,0.00005294759,0.0001758612,0.000001017304,0.000008112856,0.00001472809,0.000002564979,0.0002484638,0.9992647,0.000003303681,0.0002175025,0.000003014589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941367,0.001321465,0.002551109,0.00007167028,0.00005235684,0.00005541673,0.0001800016,0.00009839816,0.001532931],"genre_scores_gemma":[0.9944389,0.0005504066,0.003044734,0.00004018079,0.000009564969,0.00002662092,0.0001201844,0.00002783577,0.001741521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00372382,"threshold_uncertainty_score":0.007404327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003411732084966119,"score_gpt":0.2210587713763268,"score_spread":0.2176470392913607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}