{"id":"W4220971507","doi":"10.1126/sciadv.abj9815","title":"Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Providence Health Care; McMaster University; University of Saskatchewan; Sunnybrook Health Science Centre; University of Waterloo; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Sunnybrook Hospital; University of Toronto","funders":"","keywords":"Vaccination; Immune system; Immunology; Neutralizing antibody; Virology; Antibody; Hamster; Medicine; Pandemic; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Mesocricetus; Respiratory tract; Coronavirus disease 2019 (COVID-19); Biology; Respiratory system; Infectious disease (medical specialty); Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005870193,0.000122568,0.0002835814,0.000353458,0.0003436556,0.00002408534,0.0005885226,0.00002954249,0.00006967045],"category_scores_gemma":[0.003434871,0.0001028416,0.000096415,0.001877745,0.000462713,0.000371843,0.0003149754,0.0003033387,0.00003338403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000275598,"about_ca_system_score_gemma":0.001870698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006170896,"about_ca_topic_score_gemma":0.00003027011,"domain_scores_codex":[0.9953201,0.0001612898,0.000411998,0.0005692719,0.003111834,0.0004254928],"domain_scores_gemma":[0.9982969,0.0002101951,0.0001665208,0.0005343281,0.00075375,0.00003831378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004496554,0.0003658971,0.04060657,0.00006249771,0.00001522228,0.00001038117,0.0003543468,0.00006723285,0.8782785,0.0003172357,0.0003858023,0.07908665],"study_design_scores_gemma":[0.002250654,0.001057474,0.01061799,0.00004006414,0.00006656994,0.00002657735,0.0006149887,0.007100868,0.8308719,0.002427761,0.1447698,0.0001553543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892962,0.002446143,0.00004882552,0.0004974427,0.0005188983,0.0006183765,0.000007554351,0.0000442926,0.006522251],"genre_scores_gemma":[0.9903353,0.000008433097,0.0004422507,0.008923662,0.0001192424,0.0001357782,0.000001583905,0.00001049804,0.00002326575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.144384,"threshold_uncertainty_score":0.419376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1475403680216393,"score_gpt":0.4888521122535248,"score_spread":0.3413117442318854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}