{"id":"W4220971507","doi":"10.1126/sciadv.abj9815","title":"Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Providence Health Care; McMaster University; University of Saskatchewan; Sunnybrook Health Science Centre; University of Waterloo; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Sunnybrook Hospital; University of Toronto","funders":"","keywords":"Vaccination; Immune system; Immunology; Neutralizing antibody; Virology; Antibody; Hamster; Medicine; Pandemic; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Mesocricetus; Respiratory tract; Coronavirus disease 2019 (COVID-19); Biology; Respiratory system; Infectious disease (medical specialty); Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005484696,0.0005109761,0.0003489086,0.0002453573,0.0002100004,0.0002893746,0.0002593641,0.0004208702,0.001884453],"category_scores_gemma":[0.0002136187,0.0001558426,0.0002803529,0.0001136229,0.0002610788,0.0003201206,0.0001674901,0.0009512619,0.0003960657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003153551,"about_ca_system_score_gemma":0.0005890173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006933797,"about_ca_topic_score_gemma":0.0009462477,"domain_scores_codex":[0.9998503,0.00003285485,0.000008255422,0.00002457028,0.00004172155,0.0000423347],"domain_scores_gemma":[0.9998561,0.00001467304,0.00003166879,0.00001050216,0.00004130719,0.00004562289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008898511,0.002024555,0.0003794334,0.0001539112,0.00002745529,0.00006961299,0.00004888543,0.001032232,0.9851136,0.0002015516,0.0004686074,0.009590217],"study_design_scores_gemma":[0.0007478172,0.09593327,0.002750611,0.00003829063,0.0001244644,0.000321094,0.00006940623,0.002206415,0.8866592,0.0001353111,0.0109995,0.00001462263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853205,0.002044833,0.007042758,0.0003697942,0.0001780542,0.001065755,0.000746892,0.000114041,0.003117378],"genre_scores_gemma":[0.9836723,0.002998132,0.005822068,0.0001967608,0.00006708176,0.0005146544,0.001748353,0.00003028417,0.004950395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884453,"threshold_uncertainty_score":0.006304145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1475403680216393,"score_gpt":0.4888521122535248,"score_spread":0.3413117442318854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}