{"id":"W4220973733","doi":"10.1158/1538-7445.sabcs21-p1-18-17","title":"Abstract P1-18-17: Phase I study of cfi-402257, an oral ttk inhibitor, in patients with advanced solid tumors with breast cancer expansion cohorts","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; Ottawa Hospital","funders":"","keywords":"Medicine; Tolerability; Breast cancer; Cancer; Internal medicine; Oncology; Fulvestrant; Response Evaluation Criteria in Solid Tumors; Triple-negative breast cancer; Chemotherapy; Progressive disease; Adverse effect; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007443758,0.00123444,0.001258659,0.0003978211,0.0003101935,0.0006670474,0.0005947999,0.0006376478,0.002967131],"category_scores_gemma":[0.0003180126,0.0004472758,0.0006479485,0.0003850301,0.0005882565,0.0004315579,0.0002434004,0.002326089,0.0008020068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006989021,"about_ca_system_score_gemma":0.001357297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098603,"about_ca_topic_score_gemma":0.002300659,"domain_scores_codex":[0.999832,0.00005178726,0.00000882025,0.00003325466,0.00002118915,0.00005280081],"domain_scores_gemma":[0.9997081,0.00003586374,0.00005144549,0.00002399171,0.00002327102,0.0001572916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3399867,0.1086358,0.01708454,0.001457979,0.00139479,0.001051344,0.0005357454,0.007645713,0.2942124,0.0007234543,0.009621422,0.2176502],"study_design_scores_gemma":[0.204688,0.7326939,0.0204342,0.00005947346,0.000607361,0.001212672,0.0001133957,0.002746231,0.02971525,0.000264728,0.007429449,0.00003539576],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994032,0.001195701,0.0006484344,0.0002128298,0.00004188182,0.001449875,0.0009230655,0.0001058479,0.001390442],"genre_scores_gemma":[0.9891129,0.001450987,0.002008793,0.0003270798,0.00007298109,0.00211071,0.002016467,0.00003582329,0.002864271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002967131,"threshold_uncertainty_score":0.009926021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02461161288763421,"score_gpt":0.3691806278654453,"score_spread":0.3445690149778111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}