{"id":"W4220978255","doi":"10.3390/nu14061312","title":"Mechanisms of Feedback Regulation of Vitamin A Metabolism","year":2022,"lang":"en","type":"review","venue":"Nutrients","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University; NOSM University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Retinoic acid; Retinoid; Vitamin; Biology; Homeostasis; Immune system; Vitamin D and neurology; Metabolite; Metabolism; Cell biology; Biochemistry; Endocrinology; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182657,0.0002357416,0.0008089042,0.00009906811,0.00003539251,0.000004834544,0.0003934558,0.0003046051,0.0001557892],"category_scores_gemma":[0.00008848873,0.000213669,0.0003953408,0.0002533425,0.00006000115,0.000002208407,0.0002186665,0.0001299286,0.000003936223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002276911,"about_ca_system_score_gemma":0.0002204003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003325474,"about_ca_topic_score_gemma":1.711332e-7,"domain_scores_codex":[0.9985055,0.000137423,0.0005546617,0.0003540608,0.0002942678,0.0001540769],"domain_scores_gemma":[0.9987161,0.0000189627,0.0006626517,0.0004861116,0.00007746414,0.00003876965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009282131,0.0004716972,0.000005209323,0.03401383,0.0006542851,0.000003278695,0.00006142163,0.00000548111,0.0382538,0.003240145,0.001892499,0.9213055],"study_design_scores_gemma":[0.000281852,0.0001096877,0.000002665088,0.0005859872,0.0003414888,0.000008972407,0.00001512401,7.136562e-7,0.04517361,0.0003479163,0.9529542,0.0001778162],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003961495,0.9967934,0.0009898024,0.000001064148,0.0002922706,0.0003798985,0.0001017567,0.000005163203,0.001040417],"genre_scores_gemma":[0.001383648,0.9959868,0.0005902465,0.000006845852,0.00007032208,0.00007567229,0.0009316253,0.00004366539,0.0009112187],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9510617,"threshold_uncertainty_score":0.8713171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010574422176576,"score_gpt":0.2769744305191657,"score_spread":0.2568686862974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}