{"id":"W4220985884","doi":"10.1111/ene.15314","title":"Evolution from a first clinical demyelinating event to multiple sclerosis in the REFLEX trial: Regional susceptibility in the conversion to multiple sclerosis at disease onset and its amenability to subcutaneous interferon beta‐1a","year":2022,"lang":"en","type":"article","venue":"European Journal of Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Medicine; Lesion; Placebo; Multiple sclerosis; Interferon beta-1a; Post-hoc analysis; White matter; Internal medicine; Corticospinal tract; Magnetic resonance imaging; Cardiology; Pathology; Radiology; Immunology; Diffusion MRI","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001937558,0.0004563485,0.001312659,0.0001966872,0.0001626484,0.0006604965,0.0003361082,0.0004577041,0.001766326],"category_scores_gemma":[0.001412108,0.000138047,0.000725991,0.0001843873,0.0003393511,0.000341121,0.0002379354,0.001129307,0.0002648359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845843,"about_ca_system_score_gemma":0.0003796125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003678398,"about_ca_topic_score_gemma":0.0007621414,"domain_scores_codex":[0.9993017,0.0004096202,0.00005492707,0.0001134121,0.00005794466,0.00006251412],"domain_scores_gemma":[0.9988652,0.0003635382,0.0003294427,0.0001259285,0.00006820111,0.000247594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9371246,0.004309472,0.02079926,0.0004370457,0.001669625,0.0001982667,0.0001047817,0.0007400422,0.01409078,0.0001039756,0.0002207262,0.02020134],"study_design_scores_gemma":[0.262919,0.5164022,0.1984392,0.0001665586,0.005256317,0.001333417,0.0002321851,0.00327402,0.009340055,0.0005430022,0.002018641,0.00007533201],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987211,0.0006574441,0.00007545782,0.00002757666,0.00001262612,0.00007036938,0.000059829,0.000006874416,0.0003687612],"genre_scores_gemma":[0.9988691,0.000239613,0.0001425437,0.00003554797,0.00002851221,0.00007220895,0.0001403918,0.000002829727,0.0004692943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937558,"threshold_uncertainty_score":0.01024687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1864394607364475,"score_gpt":0.3538266174006585,"score_spread":0.167387156664211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}