{"id":"W4220986427","doi":"10.3389/fped.2022.796994","title":"Is It Possible to Separate the Graft-Versus-Leukemia (GVL) Effect Against B Cell Acute Lymphoblastic Leukemia From Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplant?","year":2022,"lang":"en","type":"review","venue":"Frontiers in Pediatrics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; BC Children's Hospital; University of British Columbia","funders":"Cancer Research Institute","keywords":"Medicine; Leukemia; Graft-versus-host disease; Hematopoietic stem cell transplantation; Lymphoblastic Leukemia; Disease; Immunology; Ex vivo; Transplantation; Haematopoiesis; Minimal residual disease; Stem cell; Hematopoietic stem cell; In vivo; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004986825,0.0003940495,0.0010352,0.0008979517,0.000164773,0.0008461996,0.0005834213,0.001060078,0.003934837],"category_scores_gemma":[0.0008311717,0.000161719,0.0005586058,0.0008141545,0.000374888,0.001277975,0.0004080456,0.001405276,0.001439765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003680228,"about_ca_system_score_gemma":0.00103176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007037022,"about_ca_topic_score_gemma":0.001357807,"domain_scores_codex":[0.9998806,0.00003187992,0.0000155977,0.00001960315,0.00003607425,0.00001622933],"domain_scores_gemma":[0.9997442,0.0001530587,0.0000345823,0.000006146954,0.00004649592,0.00001547586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001241211,0.00005150571,0.0001390336,0.03235405,0.0001229401,0.000151015,0.00005538699,0.0001733176,0.001957671,0.005387732,0.01894008,0.9405432],"study_design_scores_gemma":[0.00004208034,0.0001657284,0.0007938743,0.01168206,0.0002433722,0.0009888504,0.0001117917,0.00006043593,0.000553797,0.002816666,0.9825256,0.00001581615],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001099591,0.99865,0.00007465517,0.0004569016,0.0001581707,0.000002785649,0.00001231794,0.000003037186,0.0005323184],"genre_scores_gemma":[0.0006352251,0.9986355,0.0001195791,0.0002497978,0.00008739057,0.000004639417,0.00001487312,9.24206e-7,0.0002521041],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003934837,"threshold_uncertainty_score":0.01316333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281251992421563,"score_gpt":0.3043720635200006,"score_spread":0.2815595435957849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}