{"id":"W4220986427","doi":"10.3389/fped.2022.796994","title":"Is It Possible to Separate the Graft-Versus-Leukemia (GVL) Effect Against B Cell Acute Lymphoblastic Leukemia From Graft-Versus-Host Disease (GVHD) After Hematopoietic Cell Transplant?","year":2022,"lang":"en","type":"review","venue":"Frontiers in Pediatrics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; BC Children's Hospital; University of British Columbia","funders":"Cancer Research Institute","keywords":"Medicine; Leukemia; Graft-versus-host disease; Hematopoietic stem cell transplantation; Lymphoblastic Leukemia; Disease; Immunology; Ex vivo; Transplantation; Haematopoiesis; Minimal residual disease; Stem cell; Hematopoietic stem cell; In vivo; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.001287577,0.002054684,0.004049922,0.001723466,0.0004325566,0.0002991072,0.00214923,0.000988725,0.00471657],"category_scores_gemma":[0.0002130763,0.001631212,0.002407727,0.00402388,0.0003004336,0.0002184247,0.0006970683,0.003282883,0.0007930831],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.008902674,"about_ca_system_score_gemma":0.006119685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001699224,"about_ca_topic_score_gemma":0.00002991003,"domain_scores_codex":[0.9894446,0.001255065,0.001871733,0.002435779,0.002779087,0.002213746],"domain_scores_gemma":[0.9919636,0.00278997,0.0006228976,0.002824327,0.0001312859,0.001667917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05281503,0.001115707,0.005982241,0.07320108,0.003836818,0.01511753,0.007022244,0.0003802893,0.00003099464,0.000003472813,0.6149582,0.2255364],"study_design_scores_gemma":[0.01245168,0.001202347,0.0001215399,0.001425738,0.01456497,0.00001809132,0.0003087935,0.0002986745,0.0000467462,0.00001631161,0.9676163,0.001928757],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007467147,0.9677758,0.0002760898,0.0001809496,0.009388645,0.006595622,0.003811426,0.0001889028,0.004315468],"genre_scores_gemma":[0.0008359757,0.9804445,0.000452423,0.0007244632,0.001556022,0.002202618,0.002009628,0.0005668196,0.01120756],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3526581,"threshold_uncertainty_score":0.9999849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281251992421563,"score_gpt":0.3043720635200006,"score_spread":0.2815595435957849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}