{"id":"W4220986748","doi":"10.3389/fonc.2022.855182","title":"Intracranial Metastatic Disease: Present Challenges, Future Opportunities","year":2022,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; William Osler Health System; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"University of Toronto","keywords":"Medicine; Immunotherapy; Disease; Radiation therapy; Monoclonal antibody; Cancer; Immune system; Oncology; Bioinformatics; Internal medicine; Intensive care medicine; Immunology; Antibody; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006265829,0.0005585384,0.00333029,0.0005704098,0.00008830388,0.00001137371,0.0002796739,0.0002073459,0.001617799],"category_scores_gemma":[0.00007960587,0.0004392032,0.0006822197,0.0002273204,0.000153141,0.00004529731,0.0001932611,0.0009766148,0.00001639735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00149478,"about_ca_system_score_gemma":0.00212649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001471592,"about_ca_topic_score_gemma":0.00001547572,"domain_scores_codex":[0.9963837,0.00121824,0.0007984773,0.0006635104,0.0004034754,0.000532552],"domain_scores_gemma":[0.9982742,0.0002796079,0.0003647339,0.0006506142,0.00002461776,0.0004062056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001552103,0.0008690212,0.000007911193,0.01137194,0.001153481,0.0140381,0.0001048837,6.891084e-7,4.50394e-10,0.0005552275,0.04471863,0.9270249],"study_design_scores_gemma":[0.001347321,0.0008285479,0.00001923942,0.00109729,0.005120601,0.0006827063,0.00137428,0.00001238835,2.342816e-9,0.0002659327,0.9889458,0.0003058382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[6.672024e-7,0.9859122,0.00005330191,0.003752245,0.004826117,0.002069827,0.0003816708,0.00005258292,0.002951403],"genre_scores_gemma":[4.683605e-7,0.9872892,0.006470419,0.0002181667,0.001236183,0.00158964,0.001592159,0.00009468978,0.001509057],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9442272,"threshold_uncertainty_score":0.999806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1821071190568404,"score_gpt":0.3877673432461115,"score_spread":0.2056602241892711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}