{"id":"W4220987582","doi":"10.3390/cells11050887","title":"Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"TFEB; Lysosome; Programmed cell death; Cell biology; Cathepsin; Cathepsin B; Cathepsin D; Biology; Autophagy; Cathepsin C; Cathepsin L1; Cathepsin H; Chemistry; Biochemistry; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002864271,0.0001749362,0.0001834269,0.00002870538,0.0002106539,0.00001264713,0.0002002097,0.0001006291,0.0006161229],"category_scores_gemma":[0.000002436745,0.0001884306,0.0002153281,0.00008144686,0.00006321794,0.000003654601,0.00004150573,0.000161107,0.00001348245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002667526,"about_ca_system_score_gemma":0.00004808337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004178813,"about_ca_topic_score_gemma":0.00001763089,"domain_scores_codex":[0.9986842,0.00008310912,0.000294928,0.0004430487,0.0002013055,0.0002933853],"domain_scores_gemma":[0.9993552,0.000009883952,0.00009103586,0.0004183514,0.00003608709,0.00008945518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001325052,0.0001257384,0.00335114,0.00002702582,0.00001705277,0.000009389261,0.00026819,0.0005913958,0.9949676,0.000008862301,0.00006875933,0.0004323804],"study_design_scores_gemma":[0.001115679,0.0002765336,0.002692234,0.000002623422,0.00004917751,0.000009448481,0.0001186113,0.0006665565,0.8405536,0.0000749087,0.1541205,0.0003200867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842291,0.0003580066,0.01289376,0.00008915341,0.0002916708,0.000329132,0.0000618326,0.00002588133,0.001721403],"genre_scores_gemma":[0.995242,0.0000116984,0.0002787811,0.0002539388,0.0001661045,0.00004363682,0.002068615,0.00003240523,0.001902849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1544139,"threshold_uncertainty_score":0.7683977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005677712096580181,"score_gpt":0.1913481721595844,"score_spread":0.1856704600630043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}