{"id":"W4220987582","doi":"10.3390/cells11050887","title":"Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"TFEB; Lysosome; Programmed cell death; Cell biology; Cathepsin; Cathepsin B; Cathepsin D; Biology; Autophagy; Cathepsin C; Cathepsin L1; Cathepsin H; Chemistry; Biochemistry; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000800835,0.0001891054,0.0002452165,0.0002074228,0.0001923986,0.0004397853,0.0001393558,0.000217346,0.0008364895],"category_scores_gemma":[0.0001334878,0.00009917599,0.0001718882,0.0001453945,0.0002586695,0.0001946657,0.0002547836,0.0002330105,0.0002929086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003872217,"about_ca_system_score_gemma":0.000239431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089841,"about_ca_topic_score_gemma":0.0009825015,"domain_scores_codex":[0.9998797,0.00002460975,0.0000160453,0.00002359665,0.00002348915,0.00003244481],"domain_scores_gemma":[0.9998631,0.00002359963,0.00003687384,0.00001520218,0.00002058086,0.00004060275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001634514,0.00001046986,0.00127305,0.00001826393,0.000004291299,0.0001471147,0.00001836674,0.00003768578,0.9973096,0.00009417954,0.00003689394,0.0008866025],"study_design_scores_gemma":[0.00002438922,0.0001291114,0.02430357,0.000005349576,0.00002181512,0.0004254037,0.000129508,0.001636792,0.9694988,0.000120059,0.003697604,0.000007619634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968675,0.000976449,0.0008628143,0.00007952275,0.00001640089,0.000005708061,0.000236204,0.00005265967,0.0009028248],"genre_scores_gemma":[0.9985144,0.0003517588,0.0001926051,0.00001674874,0.000002426791,0.000007942062,0.0001370262,0.00001058174,0.0007666559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089841,"threshold_uncertainty_score":0.002809525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005677712096580181,"score_gpt":0.1913481721595844,"score_spread":0.1856704600630043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}