{"id":"W4220990444","doi":"10.1016/j.jhep.2022.02.020","title":"Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infection","year":2022,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Wellcome Trust","keywords":"Medicine; Clinical trial; Immunology; Immune system; HBcAg; Biomarker discovery; Biomarker; Hepatitis B virus; Hepatitis B; Virus; Biology; Internal medicine; HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007942307,0.0004500654,0.003793074,0.0009360756,0.0001277042,0.00001955286,0.0002103251,0.0005652076,0.0003867332],"category_scores_gemma":[0.0009345113,0.0003342683,0.001243198,0.0004850096,0.0001833245,0.0001718729,0.0001944577,0.001374148,0.00001750997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002209422,"about_ca_system_score_gemma":0.001513557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002297353,"about_ca_topic_score_gemma":0.00782036,"domain_scores_codex":[0.9964458,0.0006022265,0.001781915,0.0003569285,0.0003079375,0.0005052171],"domain_scores_gemma":[0.9970874,0.0008586444,0.001514203,0.000319639,0.0001330736,0.0000870195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003860239,0.0006146785,0.07325899,0.01133589,0.002179754,0.002220606,0.00007689302,0.000001304891,0.00001664525,0.000168255,0.01690312,0.8928378],"study_design_scores_gemma":[0.001113402,0.00212896,0.002465845,0.003583932,0.001363901,0.006273285,0.00000248379,0.000009623681,0.000003197801,0.00009523542,0.982698,0.0002621472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002460388,0.9938808,0.0001423111,0.0003888956,0.00182919,0.001004723,0.00009323625,0.00002001711,0.000180455],"genre_scores_gemma":[0.0004456609,0.9982367,0.0001570962,0.0001158994,0.0003991997,0.0002506974,0.00008323674,0.00006758841,0.0002439711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9657949,"threshold_uncertainty_score":0.999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09856536107990982,"score_gpt":0.3879904282165441,"score_spread":0.2894250671366342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}