{"id":"W4220990444","doi":"10.1016/j.jhep.2022.02.020","title":"Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infection","year":2022,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Wellcome Trust","keywords":"Medicine; Clinical trial; Immunology; Immune system; HBcAg; Biomarker discovery; Biomarker; Hepatitis B virus; Hepatitis B; Virus; Biology; Internal medicine; HBsAg","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001718459,0.0007574538,0.002089816,0.002297916,0.0002265564,0.001072704,0.001089863,0.00136333,0.004251925],"category_scores_gemma":[0.00182473,0.0003249144,0.001206798,0.00124063,0.0004737814,0.001250507,0.0006523056,0.002230654,0.001482559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000547026,"about_ca_system_score_gemma":0.0009058797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006517072,"about_ca_topic_score_gemma":0.001277884,"domain_scores_codex":[0.9995808,0.0001507165,0.00007202003,0.00004580867,0.0001234254,0.00002728261],"domain_scores_gemma":[0.9992847,0.0004747049,0.00009088623,0.00001705448,0.0001064141,0.00002636607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001657598,0.00009084999,0.0001064214,0.03394032,0.000214034,0.0001167003,0.0000558061,0.000300821,0.0008292559,0.003333808,0.01151513,0.949331],"study_design_scores_gemma":[0.0001322705,0.0004268924,0.001354405,0.02198264,0.0005331964,0.001248781,0.00008249511,0.0001940454,0.0007820225,0.002785726,0.9704443,0.00003321604],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001070577,0.9990746,0.00007577983,0.0001544486,0.0001172899,0.00001037145,0.000009425472,0.000004626899,0.0004463987],"genre_scores_gemma":[0.000907572,0.99821,0.0002533186,0.0002189398,0.00007883299,0.00001613801,0.00002088267,0.000001753327,0.0002925659],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004251925,"threshold_uncertainty_score":0.01422411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09856536107990982,"score_gpt":0.3879904282165441,"score_spread":0.2894250671366342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}