{"id":"W4220991830","doi":"10.1038/s41467-022-28776-w","title":"Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":388,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Science Foundation; Damon Runyon Cancer Research Foundation; Canadian Institutes of Health Research; Chemistry, Engineering and Medicine for Human Health, Stanford University; Stanford Bio-X; University of California, San Francisco; Baidu; Oregon State University; Pfizer; National Cancer Institute; National Institutes of Health","keywords":"Pseudouridine; Translation (biology); Messenger RNA; RNA; Ribosome; Computational biology; Stability (learning theory); Cell biology; Biology; Computer science; Transfer RNA; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02928427736636944,"score_gpt":0.2900866515796698,"score_spread":0.2608023742133003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}