{"id":"W4220992323","doi":"10.1515/dx-2021-0147","title":"Convoluted molecular maze of neprilysin","year":2022,"lang":"en","type":"letter","venue":"Diagnosis","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Neprilysin; Thiorphan; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001376793,0.000267765,0.0003635048,0.00009344535,0.00004157648,0.00001736748,0.0004160088,0.0005726303,0.003233977],"category_scores_gemma":[0.00006781916,0.0002898038,0.0003484811,0.0001239403,0.00004808778,0.000001332774,0.0002453888,0.0004836702,0.00001226087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002187888,"about_ca_system_score_gemma":0.00007562849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008554228,"about_ca_topic_score_gemma":0.000001794387,"domain_scores_codex":[0.9984274,0.0001439856,0.0003159805,0.0005078117,0.0003116962,0.0002931235],"domain_scores_gemma":[0.999042,0.00003564189,0.0002272704,0.0005728315,0.00008195217,0.00004031257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001396481,0.00003717392,0.0002097307,0.00007248834,0.000207007,0.00009196358,0.00002034811,0.0000506209,0.1702043,0.00003333557,0.8284896,0.0005694129],"study_design_scores_gemma":[0.0001420863,0.0001722249,0.000008087753,0.00001691882,0.00005669168,0.000003868606,0.00001084135,0.000004995415,0.3516746,0.00007635849,0.6476188,0.0002145474],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5720424,0.03026686,0.007240944,0.3711602,0.006319677,0.003007087,0.002829045,0.0001775278,0.006956224],"genre_scores_gemma":[0.1325011,0.002967188,0.002630739,0.8419167,0.003802731,0.001287457,0.01123923,0.0003862021,0.00326867],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4707565,"threshold_uncertainty_score":0.9999554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001132737745736,"score_gpt":0.2256640602368317,"score_spread":0.2156527328593744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}