{"id":"W4220992323","doi":"10.1515/dx-2021-0147","title":"Convoluted molecular maze of neprilysin","year":2022,"lang":"en","type":"letter","venue":"Diagnosis","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Neprilysin; Thiorphan; Chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001791036,0.000557975,0.001256324,0.001037013,0.001728232,0.002745436,0.001491444,0.01602435,0.004883102],"category_scores_gemma":[0.01083257,0.0004112759,0.0007171411,0.0004968041,0.003766639,0.002497016,0.0009134837,0.01411057,0.003073471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00564687,"about_ca_system_score_gemma":0.001887798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001562155,"about_ca_topic_score_gemma":0.002171452,"domain_scores_codex":[0.9985067,0.0004438143,0.0002206251,0.000168663,0.0004110817,0.0002488946],"domain_scores_gemma":[0.9939255,0.00387467,0.0003257607,0.0004184801,0.0008324857,0.0006231698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007197132,0.0001054613,0.001436301,0.0002937976,0.00004380956,0.0902279,0.000136794,0.0004456605,0.002400043,0.06357746,0.7972866,0.04332658],"study_design_scores_gemma":[0.0004219143,0.0001785896,0.002096002,0.0003385011,0.00006225575,0.05284399,0.0002277703,0.003231457,0.002496127,0.1883996,0.7496199,0.00008389996],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.005725241,0.009125859,0.001584199,0.922155,0.03642608,0.00004262356,0.0001865254,0.0001062727,0.02464824],"genre_scores_gemma":[0.1299888,0.01321599,0.004548547,0.3999423,0.398367,0.0001484004,0.000254782,0.0001158476,0.05341824],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01602435,"threshold_uncertainty_score":0.0409711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001132737745736,"score_gpt":0.2256640602368317,"score_spread":0.2156527328593744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}