{"id":"W4220992753","doi":"10.1038/s42003-022-03235-w","title":"Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Western Economic Diversification Canada; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Compute Canada; Canadian Institutes of Health Research; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Canada Foundation for Innovation; Government of Canada; University of Saskatchewan","keywords":"Gp41; Virology; Human immunodeficiency virus (HIV); Antibody; Neutralizing antibody; Plasticity; Biology; Epitope; Immunology; Physics; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421391,0.0002000917,0.0001992551,0.00008769512,0.0002399121,0.0003293263,0.0002531349,0.0002188405,0.0006264717],"category_scores_gemma":[0.0002062385,0.0001624055,0.0002254733,0.00007379978,0.0002856821,0.0003221323,0.0001777919,0.0003450574,0.00009414068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310535,"about_ca_system_score_gemma":0.0003279608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001020845,"about_ca_topic_score_gemma":0.00130374,"domain_scores_codex":[0.9999259,0.00001715543,0.00000265284,0.00001268973,0.00001931861,0.00002240368],"domain_scores_gemma":[0.9999446,0.00001830719,0.00001447613,0.000005039334,0.000006392942,0.00001120213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004584157,0.0003114117,0.02757387,0.0002058826,0.0001911836,0.0008222143,0.0001892383,0.2079048,0.7326906,0.01164047,0.0006005165,0.01741157],"study_design_scores_gemma":[0.0001103624,0.0005384703,0.03974905,0.00002644159,0.0001032538,0.0006505686,0.0002725539,0.8429208,0.1053808,0.007691198,0.002500096,0.00005631741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960757,0.0001746086,0.002689397,0.00004847517,0.000004896944,0.000004819691,0.00001953679,0.00002390102,0.0009585809],"genre_scores_gemma":[0.9991583,0.0001147186,0.0005374695,0.00002005022,0.000001699176,0.000004914966,0.0000306598,0.00000418031,0.0001280287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020845,"threshold_uncertainty_score":0.002253115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03792173649562315,"score_gpt":0.2912301773697751,"score_spread":0.253308440874152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}