{"id":"W4220997556","doi":"10.1042/bcj20210741","title":"Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin","year":2022,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Parkin; Ubiquitin; Ubiquitin ligase; PINK1; Phosphorylation; Ubiquitin-Protein Ligases; Cell biology; Deubiquitinating enzyme; Chemistry; Fusion protein; Biochemistry; Biology; Mitophagy; Autophagy; Gene; Recombinant DNA; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502592,0.0001629219,0.0001565538,0.00008130413,0.000103015,0.0003696795,0.0001608,0.0001652434,0.0007492979],"category_scores_gemma":[0.0001537911,0.0001478348,0.0001679185,0.00007816348,0.000167027,0.0002702227,0.0002527519,0.0002855661,0.0002400683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766713,"about_ca_system_score_gemma":0.00008888178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001152687,"about_ca_topic_score_gemma":0.0002173344,"domain_scores_codex":[0.9998931,0.00001447605,0.00001172315,0.0000294905,0.00002434251,0.0000269745],"domain_scores_gemma":[0.9998505,0.0000347039,0.00004959673,0.00001915101,0.00001204866,0.00003398265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001193912,0.00001297743,0.0004221337,0.00001872325,0.000002448995,0.00004507123,0.00001112827,0.00006182465,0.9983625,0.0002005512,0.0000136951,0.0007295827],"study_design_scores_gemma":[0.00001068545,0.00008492414,0.004973615,0.000002844321,0.000005538895,0.0001959727,0.00002601258,0.001986285,0.9918929,0.0001154723,0.000702246,0.000003465756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985197,0.0002766271,0.0007741796,0.00002469452,0.000004789626,0.000003708213,0.00004321654,0.00001808033,0.0003350456],"genre_scores_gemma":[0.9987845,0.0001439262,0.0005354202,0.00001434751,0.000001387835,0.000003612163,0.00008110888,0.000007924174,0.0004278346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007492979,"threshold_uncertainty_score":0.002506614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126390766182804,"score_gpt":0.2429812138638375,"score_spread":0.2303421372455571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}