{"id":"W4221000304","doi":"10.1038/s41375-022-01529-w","title":"Monoclonal proteinuria predicts progression risk in asymptomatic multiple myeloma with a free light chain ratio ≥100","year":2022,"lang":"en","type":"letter","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute","keywords":"Asymptomatic; Multiple myeloma; Proteinuria; AL amyloidosis; Excretion; Gastroenterology; Medicine; Immunoglobulin light chain; Internal medicine; Urine; Amyloidosis; Retrospective cohort study; Urology; Kidney; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004362724,0.0008013726,0.001088021,0.0006957891,0.0002831744,0.00009310965,0.0005957207,0.000796016,0.00100568],"category_scores_gemma":[0.0006407275,0.0005783242,0.0002230405,0.0006731605,0.0001410868,0.0001611362,0.0003783987,0.004284298,0.0001171517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002996616,"about_ca_system_score_gemma":0.001977958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027386,"about_ca_topic_score_gemma":0.0003946357,"domain_scores_codex":[0.9940879,0.0005955855,0.0007352233,0.001157529,0.002215366,0.001208368],"domain_scores_gemma":[0.997154,0.0003309022,0.0004885608,0.001564329,0.0001239472,0.000338278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005763685,0.0007391553,0.1726678,0.002611269,0.001416737,0.03816192,0.001441152,0.00008402794,0.0004378795,0.000006019617,0.7543495,0.0223209],"study_design_scores_gemma":[0.07527027,0.01174311,0.2026101,0.007828083,0.0009880899,0.001469936,0.0002065475,0.03686016,0.004467823,0.0003292748,0.6557234,0.002503216],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6672596,0.00239927,0.0001927295,0.292172,0.0006436509,0.02814096,0.00140046,0.001053037,0.006738198],"genre_scores_gemma":[0.6353172,0.0005756908,0.03911018,0.1601046,0.0168667,0.05862559,0.02502858,0.00217535,0.0621961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1320674,"threshold_uncertainty_score":0.9999076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456357798909336,"score_gpt":0.2679453236427972,"score_spread":0.2533817456537039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}