{"id":"W4221000304","doi":"10.1038/s41375-022-01529-w","title":"Monoclonal proteinuria predicts progression risk in asymptomatic multiple myeloma with a free light chain ratio ≥100","year":2022,"lang":"en","type":"letter","venue":"Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute","keywords":"Asymptomatic; Multiple myeloma; Proteinuria; AL amyloidosis; Excretion; Gastroenterology; Medicine; Immunoglobulin light chain; Internal medicine; Urine; Amyloidosis; Retrospective cohort study; Urology; Kidney; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006489964,0.0002940247,0.0007475815,0.0008234199,0.00102646,0.001103955,0.0004898436,0.004341378,0.002126851],"category_scores_gemma":[0.00618993,0.0002721754,0.0004801697,0.0007976564,0.0003807108,0.0006690017,0.0002911676,0.003405209,0.0006585945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008285093,"about_ca_system_score_gemma":0.001100592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006315304,"about_ca_topic_score_gemma":0.009321758,"domain_scores_codex":[0.9995289,0.0001428175,0.00005358598,0.0000534172,0.0001052787,0.0001159188],"domain_scores_gemma":[0.9972332,0.001369971,0.0002481494,0.00008941338,0.0003562945,0.0007030299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001334147,0.0003660538,0.856788,0.00005138852,0.00008881003,0.02928388,0.0002514551,0.0002796442,0.001082018,0.0007125665,0.07692643,0.03283554],"study_design_scores_gemma":[0.0007710927,0.001364356,0.7943088,0.0003285485,0.0005101479,0.1317488,0.001698529,0.01056608,0.001197869,0.01004638,0.04729746,0.000161916],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.608726,0.005463555,0.0007367954,0.34595,0.005856969,0.00005776804,0.0008878699,0.0001630763,0.03215806],"genre_scores_gemma":[0.9268395,0.001479629,0.0006650885,0.05450049,0.01118171,0.0000263881,0.0003196405,0.0000281033,0.004959497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006315304,"threshold_uncertainty_score":0.01255709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456357798909336,"score_gpt":0.2679453236427972,"score_spread":0.2533817456537039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}