{"id":"W4221003301","doi":"10.1038/s41398-022-01899-w","title":"APOE-ε4 modulates the association among plasma Aβ42/Aβ40, vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults","year":2022,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Shenzhen Bay Laboratory; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Cognitive decline; Internal medicine; Neurodegeneration; Cognition; Alzheimer's Disease Neuroimaging Initiative; Psychology; Medicine; Dementia; Body mass index; Endocrinology; Cardiology; Neuroscience; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003430126,0.0002828699,0.0002009091,0.0003265777,0.0002503562,0.0003974127,0.0001869099,0.0003769515,0.001185489],"category_scores_gemma":[0.0008869561,0.0002113104,0.0002862754,0.0002667277,0.0001533336,0.0002213106,0.0001969736,0.0002959159,0.0002098523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035627,"about_ca_system_score_gemma":0.0001288523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002898808,"about_ca_topic_score_gemma":0.003605007,"domain_scores_codex":[0.9999088,0.0000238265,0.00001066693,0.00002382137,0.00001543202,0.00001755722],"domain_scores_gemma":[0.9996712,0.0000732651,0.0001312925,0.0000293519,0.00003404386,0.00006078503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005420587,0.00008085059,0.9963096,0.00001157208,0.0001314267,0.0001492997,0.00009977241,0.00003173896,0.001199801,0.00001803121,0.0000559971,0.001369926],"study_design_scores_gemma":[0.000003713627,0.00008074574,0.9994971,0.000001764142,0.00002764044,0.0001042617,0.00004748526,0.00008261107,0.00008547462,0.00001984446,0.00004815326,0.00000109861],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999632,0.000134809,0.000028544,0.00001291179,0.00000255478,0.000002055696,0.00004916277,0.000001214175,0.000136764],"genre_scores_gemma":[0.9996088,0.00005587193,0.00004376472,0.00001423002,0.000005017016,0.000002139326,0.00005801169,7.290528e-7,0.0002115253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002898808,"threshold_uncertainty_score":0.005763888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005751724149068833,"score_gpt":0.2561695276589008,"score_spread":0.250417803509832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}