{"id":"W4221003929","doi":"10.1016/j.scr.2022.102750","title":"Generation of two induced pluripotent stem cell lines (UQACi002-A and UQACi005-A) from two patients with KRT14 epidermolysis bullosa simplex mutations","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université Laval; Université du Québec à Chicoutimi","funders":"Fondation du Grand défi Pierre Lavoie; Rare Disease Foundation; Université du Québec à Chicoutimi","keywords":"Epidermolysis bullosa simplex; Induced pluripotent stem cell; Sendai virus; Biology; Keratin 14; Germ layer; Keratin; Cell culture; Cell biology; Gene; Genetics; Embryonic stem cell; Transgene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537569,0.0003388826,0.0003721767,0.0007514521,0.0003750347,0.0003930527,0.0002619282,0.000830297,0.004346849],"category_scores_gemma":[0.00057346,0.0002114736,0.0005165765,0.0003046371,0.0003200214,0.0002113525,0.0005151191,0.0006937806,0.0005932096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240795,"about_ca_system_score_gemma":0.0002388763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006685593,"about_ca_topic_score_gemma":0.0005322133,"domain_scores_codex":[0.9997517,0.00003179248,0.00005044105,0.00006641261,0.00006316283,0.00003652706],"domain_scores_gemma":[0.9998461,0.00003244109,0.00001688449,0.00003428485,0.00002221023,0.00004800347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008020937,0.0005540004,0.01761815,0.0001944001,0.0000877051,0.01288332,0.001130438,0.0004343683,0.9198328,0.002541486,0.001640588,0.04228067],"study_design_scores_gemma":[0.001471441,0.004222828,0.09472031,0.0001391488,0.000350441,0.1333499,0.001016911,0.004974261,0.7060856,0.001130527,0.05239564,0.0001430444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821545,0.00105728,0.009733023,0.0004992436,0.0001897374,0.0005234763,0.001734161,0.0001369815,0.003971577],"genre_scores_gemma":[0.9802397,0.0007309515,0.01036606,0.0004197101,0.00005015338,0.0003972606,0.003377367,0.00003916587,0.004379653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004346849,"threshold_uncertainty_score":0.01454163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06613923956751443,"score_gpt":0.3291791741622376,"score_spread":0.2630399345947232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}