{"id":"W4221004188","doi":"10.1158/1538-7445.sabcs21-ot2-25-01","title":"Abstract OT2-25-01: Irene study: Phase 2 study of Incmga00012 and the oncolytic virus pelareorep in metastatic triple negative breast cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Oncolytic virus; Medicine; Breast cancer; Triple-negative breast cancer; Tumor microenvironment; Metastatic breast cancer; Cancer; Internal medicine; Oncology; Immunotherapy; CD8; Cancer research; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00135467,0.001327429,0.001390733,0.0003048637,0.0002878088,0.001089521,0.0008460488,0.001362752,0.005491537],"category_scores_gemma":[0.0004719452,0.0004901439,0.0009140758,0.0002450057,0.0006489457,0.0007112107,0.0002580898,0.003460384,0.0009372995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009052934,"about_ca_system_score_gemma":0.001203236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069103,"about_ca_topic_score_gemma":0.003061239,"domain_scores_codex":[0.9997622,0.00009561519,0.000007580512,0.00003673475,0.00002953865,0.0000682757],"domain_scores_gemma":[0.9996159,0.00004815256,0.00005602269,0.00003108578,0.00002333349,0.0002254775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6070207,0.1406891,0.005625556,0.001411104,0.001423652,0.000604753,0.0003453618,0.00319635,0.09834027,0.0008535283,0.01458758,0.125902],"study_design_scores_gemma":[0.5011699,0.4735323,0.009460839,0.00007484177,0.000413538,0.0005423324,0.00007939885,0.001540041,0.006473168,0.000261203,0.006412254,0.00004034812],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884886,0.001986597,0.0005066824,0.0006046137,0.0001517609,0.002735344,0.001446856,0.0001413026,0.003938184],"genre_scores_gemma":[0.9754999,0.002096617,0.002003,0.001483032,0.0002181298,0.003807754,0.003826281,0.00005082969,0.01101442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005491537,"threshold_uncertainty_score":0.01837099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06852457087173387,"score_gpt":0.4446651331476729,"score_spread":0.376140562275939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}