{"id":"W4221005328","doi":"10.1371/journal.ppat.1010099","title":"Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Vaccinia; Biology; RNA splicing; Gene; Messenger RNA; RNA; Intron; Translation (biology); Virus; Cell biology; Alternative splicing; Gene expression; Transcriptome; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003552491,0.0002667361,0.0003835412,0.0001715894,0.001261674,0.00004756747,0.0004734286,0.0001986229,0.005510545],"category_scores_gemma":[0.00007406699,0.0002684351,0.0001687716,0.0002757355,0.0001184749,0.0001281562,0.0005557503,0.0008744482,0.0009291507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001680561,"about_ca_system_score_gemma":0.0001318813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006139601,"about_ca_topic_score_gemma":0.00005073505,"domain_scores_codex":[0.9976475,0.0005018156,0.0002307698,0.0005745219,0.0001578189,0.0008876191],"domain_scores_gemma":[0.9989918,0.000164597,0.0001417752,0.0005642803,0.00004979439,0.0000876928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003184815,0.0002775872,0.001733121,0.00001398843,0.0003333619,0.00004237207,0.0007531735,0.000003344416,0.9603069,0.00001194493,0.02663111,0.009574556],"study_design_scores_gemma":[0.00104148,0.0002191887,0.004595246,0.00001508926,0.00006898817,0.00007741942,0.0001851535,0.00009139143,0.8917463,0.00005205748,0.1015872,0.0003204705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993347,0.002681211,0.00004339421,0.0007529214,0.0002718645,0.0003606621,0.001126178,0.0001853656,0.001231383],"genre_scores_gemma":[0.9947745,0.0001485489,0.0000245057,0.0006614997,0.00003415336,0.00008770581,0.000209272,0.00004439244,0.004015415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07495607,"threshold_uncertainty_score":0.9999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03900247067727355,"score_gpt":0.2565264820826004,"score_spread":0.2175240114053269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}