{"id":"W4221005328","doi":"10.1371/journal.ppat.1010099","title":"Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Vaccinia; Biology; RNA splicing; Gene; Messenger RNA; RNA; Intron; Translation (biology); Virus; Cell biology; Alternative splicing; Gene expression; Transcriptome; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035013,0.0003731356,0.0002251597,0.0001495863,0.0001450473,0.0004016108,0.0001371163,0.0002334775,0.0005864805],"category_scores_gemma":[0.000203627,0.00019964,0.000238142,0.00011586,0.0002611716,0.000122813,0.0002459316,0.0002980724,0.000355709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829091,"about_ca_system_score_gemma":0.0002012542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004753722,"about_ca_topic_score_gemma":0.000681882,"domain_scores_codex":[0.9998009,0.00003269252,0.00002015115,0.00006922129,0.00004467549,0.00003239541],"domain_scores_gemma":[0.9997643,0.00006739185,0.00005869681,0.0000322828,0.00003125082,0.00004611064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002842341,0.00000401817,0.0003906882,0.00001447687,0.000001624939,0.00002185432,0.000004905113,0.00002352203,0.9987636,0.00003081774,0.000007029044,0.0007090196],"study_design_scores_gemma":[0.000005423423,0.0002402408,0.005252521,0.000004311905,0.000007200521,0.0005324256,0.0000227503,0.0004289057,0.9911125,0.00005008827,0.002339398,0.000004170948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912793,0.001343608,0.005711513,0.00005926303,0.00002125097,0.00002096389,0.0001888404,0.00005320254,0.001322106],"genre_scores_gemma":[0.9930874,0.0006478237,0.004246581,0.00006538577,0.000007640067,0.00001625801,0.0006436583,0.00002959758,0.001255593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005864805,"threshold_uncertainty_score":0.002052665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03900247067727355,"score_gpt":0.2565264820826004,"score_spread":0.2175240114053269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}