{"id":"W4221005337","doi":"10.1038/s41598-022-07590-w","title":"A SARS-CoV-2 Wuhan spike virosome vaccine induces superior neutralization breadth compared to one using the Beta spike","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Horizon 2020; Bill and Melinda Gates Foundation; Amsterdam University Medical Centers; Howard Hughes Medical Institute","keywords":"Neutralization; Virology; Heterologous; Immunogenicity; Neutralizing antibody; Vaccination; Spike (software development); Antibody; Spike Protein; Biology; BETA (programming language); Virus; Medicine; Coronavirus disease 2019 (COVID-19); Immunology; Infectious disease (medical specialty); Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992329,0.000280903,0.0002638615,0.0001566355,0.0000753943,0.0001951697,0.0001092921,0.0002730953,0.0008915561],"category_scores_gemma":[0.0001482317,0.00009417516,0.0001975405,0.00007600558,0.0001573203,0.0002902389,0.000158544,0.0004361192,0.0001324586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001751758,"about_ca_system_score_gemma":0.0001794167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002779726,"about_ca_topic_score_gemma":0.0004769835,"domain_scores_codex":[0.9998671,0.00002085909,0.00001243806,0.00002816448,0.00003912526,0.00003233339],"domain_scores_gemma":[0.9999377,0.00001556487,0.00001661006,0.000007353572,0.00000844509,0.00001444531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001860683,0.0001330768,0.0004240265,0.00002240326,0.000009153153,0.0000144977,0.00001098053,0.00009345933,0.9972616,0.00007876561,0.00002573485,0.001740127],"study_design_scores_gemma":[0.0000848796,0.005655001,0.008032339,0.000006916702,0.00004201284,0.0003247865,0.00002613557,0.001030088,0.9835715,0.00007851322,0.001141034,0.000006769395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983554,0.0001780875,0.0007749788,0.0000270627,0.00001303766,0.00001862222,0.00005468188,0.00001471333,0.0005633216],"genre_scores_gemma":[0.997672,0.0001563506,0.001192908,0.00004709056,0.000008685436,0.00001372522,0.00024309,0.000006809382,0.0006593281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008915561,"threshold_uncertainty_score":0.002982557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09457313679497316,"score_gpt":0.3642372351782943,"score_spread":0.2696640983833211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}